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Topical tacalcitol and 308-nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo.
Photodermatol Photoimmunol Photomed. 2006 Dec; 22(6):310-4.PP

Abstract

BACKGROUND/PURPOSE

To study and compare the efficacy of combined 308-nm monochromatic excimer light (MEL) therapy with tacalcitol vs. that of MEL 308-nm therapy alone in treatment of vitiligo.

METHODS

Thirty-eight patients with vitiligo were enrolled in a single-blind, within patient controlled clinical trial. Symmetrical or nearby lesions were randomly applied with either topical tacalcitol cream or vehicle. Each lesion was treated weekly with the 308-nm MEL, for a total of 12 sessions. Patients were examined at monthly intervals. The mean number of sessions and the cumulative dosage for initial repigmentation were calculated.

RESULT

Thirty-five patients were evaluated. Treatment with tacalcitol and MEL resulted in higher percentages for excellent repigmentation (25.7%) compared with vehicle and MEL (5.7%) (P<0.05). Percentages for total response were 71.4% and 60%, respectively (P>0.05). The mean+/-SEM cumulative dose and number of excimer light exposures for initial repigmentation were, respectively, 3.93+/-0.59 J/cm2 and 4.52+/-0.49 at the tacalcitol side, and, respectively, 4.99+/-0.68 J/cm2 and 5.3+/-0.52 at the vehicle side (P<0.05).

CONCLUSION

Our results have shown that concurrent topical tacalcitol potentiates the efficacy of the 308-nm MEL in the treatment of vitiligo, and that this combination achieves earlier pigmentation with a lower total dosage.

Authors+Show Affiliations

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17100739

Citation

Lu-yan, Tang, et al. "Topical Tacalcitol and 308-nm Monochromatic Excimer Light: a Synergistic Combination for the Treatment of Vitiligo." Photodermatology, Photoimmunology & Photomedicine, vol. 22, no. 6, 2006, pp. 310-4.
Lu-yan T, Wen-wen F, Lei-hong X, et al. Topical tacalcitol and 308-nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo. Photodermatol Photoimmunol Photomed. 2006;22(6):310-4.
Lu-yan, T., Wen-wen, F., Lei-hong, X., Yi, J., & Zhi-zhong, Z. (2006). Topical tacalcitol and 308-nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo. Photodermatology, Photoimmunology & Photomedicine, 22(6), 310-4.
Lu-yan T, et al. Topical Tacalcitol and 308-nm Monochromatic Excimer Light: a Synergistic Combination for the Treatment of Vitiligo. Photodermatol Photoimmunol Photomed. 2006;22(6):310-4. PubMed PMID: 17100739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical tacalcitol and 308-nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo. AU - Lu-yan,Tang, AU - Wen-wen,Fu, AU - Lei-hong,Xiang, AU - Yi,Jin, AU - Zhi-zhong,Zheng, PY - 2006/11/15/pubmed PY - 2007/2/16/medline PY - 2006/11/15/entrez SP - 310 EP - 4 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 22 IS - 6 N2 - BACKGROUND/PURPOSE: To study and compare the efficacy of combined 308-nm monochromatic excimer light (MEL) therapy with tacalcitol vs. that of MEL 308-nm therapy alone in treatment of vitiligo. METHODS: Thirty-eight patients with vitiligo were enrolled in a single-blind, within patient controlled clinical trial. Symmetrical or nearby lesions were randomly applied with either topical tacalcitol cream or vehicle. Each lesion was treated weekly with the 308-nm MEL, for a total of 12 sessions. Patients were examined at monthly intervals. The mean number of sessions and the cumulative dosage for initial repigmentation were calculated. RESULT: Thirty-five patients were evaluated. Treatment with tacalcitol and MEL resulted in higher percentages for excellent repigmentation (25.7%) compared with vehicle and MEL (5.7%) (P<0.05). Percentages for total response were 71.4% and 60%, respectively (P>0.05). The mean+/-SEM cumulative dose and number of excimer light exposures for initial repigmentation were, respectively, 3.93+/-0.59 J/cm2 and 4.52+/-0.49 at the tacalcitol side, and, respectively, 4.99+/-0.68 J/cm2 and 5.3+/-0.52 at the vehicle side (P<0.05). CONCLUSION: Our results have shown that concurrent topical tacalcitol potentiates the efficacy of the 308-nm MEL in the treatment of vitiligo, and that this combination achieves earlier pigmentation with a lower total dosage. SN - 0905-4383 UR - https://www.unboundmedicine.com/medline/citation/17100739/Topical_tacalcitol_and_308_nm_monochromatic_excimer_light:_a_synergistic_combination_for_the_treatment_of_vitiligo_ L2 - https://doi.org/10.1111/j.1600-0781.2006.00250.x DB - PRIME DP - Unbound Medicine ER -