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Vagus-brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD.
Atherosclerosis. 2007 Dec; 195(2):e1-9.A

Abstract

The current understanding of the pathophysiology of atherosclerosis leading to coronary artery disease (CAD) emphasizes the role of inflammatory mediators. Given the bidirectional communication between the immune and central nervous systems, an important question is whether the brain can be "informed" about and modulate CAD-related inflammation. A candidate communicator and modulator is the vagus nerve. Until now, the vagus nerve has received attention in cardiology mainly due to its role in the parasympathetic cardiovascular response. However, the vagus nerve can also "inform" the brain about peripheral inflammation since its paraganglia have receptors for interleukin-1. Furthermore, its efferent branch has a local anti-inflammatory effect. These effects have not been considered in research on the vagus nerve in CAD or in vagus nerve stimulation trials in CAD. In addition, various behavioural interventions, including relaxation, may influence CAD prognosis by affecting vagal activity. Based on this converging evidence, we propose a neuroimmunomodulation approach to atherogenesis. In this model, the vagus nerve "informs" the brain about CAD-related cytokines; in turn, activation of the vagus (via vagus nerve stimulation, vagomimetic drugs or relaxation) induces an anti-inflammatory response that can slow down the chronic process of atherogenesis.

Authors+Show Affiliations

CoRPS (Center of Research on Psychology in Somatic Diseases), Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands. Y.Gidron@uvt.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17101139

Citation

Gidron, Yori, et al. "Vagus-brain Communication in Atherosclerosis-related Inflammation: a Neuroimmunomodulation Perspective of CAD." Atherosclerosis, vol. 195, no. 2, 2007, pp. e1-9.
Gidron Y, Kupper N, Kwaijtaal M, et al. Vagus-brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD. Atherosclerosis. 2007;195(2):e1-9.
Gidron, Y., Kupper, N., Kwaijtaal, M., Winter, J., & Denollet, J. (2007). Vagus-brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD. Atherosclerosis, 195(2), e1-9.
Gidron Y, et al. Vagus-brain Communication in Atherosclerosis-related Inflammation: a Neuroimmunomodulation Perspective of CAD. Atherosclerosis. 2007;195(2):e1-9. PubMed PMID: 17101139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vagus-brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD. AU - Gidron,Yori, AU - Kupper,Nina, AU - Kwaijtaal,Martijn, AU - Winter,Jobst, AU - Denollet,Johan, Y1 - 2006/11/13/ PY - 2006/05/15/received PY - 2006/09/19/revised PY - 2006/10/02/accepted PY - 2006/11/15/pubmed PY - 2008/1/5/medline PY - 2006/11/15/entrez SP - e1 EP - 9 JF - Atherosclerosis JO - Atherosclerosis VL - 195 IS - 2 N2 - The current understanding of the pathophysiology of atherosclerosis leading to coronary artery disease (CAD) emphasizes the role of inflammatory mediators. Given the bidirectional communication between the immune and central nervous systems, an important question is whether the brain can be "informed" about and modulate CAD-related inflammation. A candidate communicator and modulator is the vagus nerve. Until now, the vagus nerve has received attention in cardiology mainly due to its role in the parasympathetic cardiovascular response. However, the vagus nerve can also "inform" the brain about peripheral inflammation since its paraganglia have receptors for interleukin-1. Furthermore, its efferent branch has a local anti-inflammatory effect. These effects have not been considered in research on the vagus nerve in CAD or in vagus nerve stimulation trials in CAD. In addition, various behavioural interventions, including relaxation, may influence CAD prognosis by affecting vagal activity. Based on this converging evidence, we propose a neuroimmunomodulation approach to atherogenesis. In this model, the vagus nerve "informs" the brain about CAD-related cytokines; in turn, activation of the vagus (via vagus nerve stimulation, vagomimetic drugs or relaxation) induces an anti-inflammatory response that can slow down the chronic process of atherogenesis. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/17101139/Vagus_brain_communication_in_atherosclerosis_related_inflammation:_a_neuroimmunomodulation_perspective_of_CAD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(06)00616-2 DB - PRIME DP - Unbound Medicine ER -