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Intestinal transplantation for short bowel syndrome secondary to gastroschisis.
J Pediatr Surg. 2006 Nov; 41(11):1841-5.JP

Abstract

BACKGROUND/PURPOSE

Gastroschisis is the most frequent cause of pediatric intestinal transplantation. This study reviews our experience of intestinal transplantation secondary to gastroschisis to elucidate those factors affecting the outcome of children with short bowel syndrome.

METHODS

A retrospective review was performed for children who underwent intestinal transplantation for gastroschisis at the University of Miami between June 2003 and August 1994.

RESULTS

Thirty-two transplants were performed in 28 children with gastroschisis during the study period. Associated intestinal anomalies were present in 22 infants (atresia [n = 14], volvulus [n = 3], and/or ischemia [n = 16]). Spontaneous prenatal closure of gastroschisis, a rare anomaly associated with bowel atresia and ischemia because of a very small abdominal defect, was seen in 9 patients. Most of the patients had a complicated course and required multiple abdominal surgeries before transplant. Fifteen (53.6%) patients are currently alive at a median follow-up of 23.5 months. Short-term survival rate has significantly improved in recent years.

CONCLUSIONS

Patients with complex gastroschisis and intestinal anomalies have a significant risk for progression to short bowel syndrome. Intestinal transplantation can be a lifesaving option and provides a satisfactory outcome for children with short bowel syndrome secondary to gastroschisis.

Authors+Show Affiliations

Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai 980-8574, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17101355

Citation

Wada, Motoshi, et al. "Intestinal Transplantation for Short Bowel Syndrome Secondary to Gastroschisis." Journal of Pediatric Surgery, vol. 41, no. 11, 2006, pp. 1841-5.
Wada M, Kato T, Hayashi Y, et al. Intestinal transplantation for short bowel syndrome secondary to gastroschisis. J Pediatr Surg. 2006;41(11):1841-5.
Wada, M., Kato, T., Hayashi, Y., Selvaggi, G., Mittal, N., Thompson, J., Gonzalez, M., Nishida, S., Madariaga, J., & Tzakis, A. (2006). Intestinal transplantation for short bowel syndrome secondary to gastroschisis. Journal of Pediatric Surgery, 41(11), 1841-5.
Wada M, et al. Intestinal Transplantation for Short Bowel Syndrome Secondary to Gastroschisis. J Pediatr Surg. 2006;41(11):1841-5. PubMed PMID: 17101355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal transplantation for short bowel syndrome secondary to gastroschisis. AU - Wada,Motoshi, AU - Kato,Tomoaki, AU - Hayashi,Yutaka, AU - Selvaggi,G, AU - Mittal,N, AU - Thompson,J, AU - Gonzalez,M, AU - Nishida,S, AU - Madariaga,J, AU - Tzakis,A, PY - 2006/11/15/pubmed PY - 2006/12/9/medline PY - 2006/11/15/entrez SP - 1841 EP - 5 JF - Journal of pediatric surgery JO - J Pediatr Surg VL - 41 IS - 11 N2 - BACKGROUND/PURPOSE: Gastroschisis is the most frequent cause of pediatric intestinal transplantation. This study reviews our experience of intestinal transplantation secondary to gastroschisis to elucidate those factors affecting the outcome of children with short bowel syndrome. METHODS: A retrospective review was performed for children who underwent intestinal transplantation for gastroschisis at the University of Miami between June 2003 and August 1994. RESULTS: Thirty-two transplants were performed in 28 children with gastroschisis during the study period. Associated intestinal anomalies were present in 22 infants (atresia [n = 14], volvulus [n = 3], and/or ischemia [n = 16]). Spontaneous prenatal closure of gastroschisis, a rare anomaly associated with bowel atresia and ischemia because of a very small abdominal defect, was seen in 9 patients. Most of the patients had a complicated course and required multiple abdominal surgeries before transplant. Fifteen (53.6%) patients are currently alive at a median follow-up of 23.5 months. Short-term survival rate has significantly improved in recent years. CONCLUSIONS: Patients with complex gastroschisis and intestinal anomalies have a significant risk for progression to short bowel syndrome. Intestinal transplantation can be a lifesaving option and provides a satisfactory outcome for children with short bowel syndrome secondary to gastroschisis. SN - 1531-5037 UR - https://www.unboundmedicine.com/medline/citation/17101355/Intestinal_transplantation_for_short_bowel_syndrome_secondary_to_gastroschisis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3468(06)00458-1 DB - PRIME DP - Unbound Medicine ER -