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The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity.
J Clin Pharmacol. 2006 Dec; 46(12):1481-6.JC

Abstract

Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long-term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R2 = .0947, P < .0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R2 = .0741, P < .0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects.

Authors+Show Affiliations

University of Oklahoma College of Pharmacy, Department of Pharmacy, Tulsa, Oklahoma 74315-2512, USA. ryan-carnahan@ouhsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17101747

Citation

Carnahan, Ryan M., et al. "The Anticholinergic Drug Scale as a Measure of Drug-related Anticholinergic Burden: Associations With Serum Anticholinergic Activity." Journal of Clinical Pharmacology, vol. 46, no. 12, 2006, pp. 1481-6.
Carnahan RM, Lund BC, Perry PJ, et al. The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol. 2006;46(12):1481-6.
Carnahan, R. M., Lund, B. C., Perry, P. J., Pollock, B. G., & Culp, K. R. (2006). The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. Journal of Clinical Pharmacology, 46(12), 1481-6.
Carnahan RM, et al. The Anticholinergic Drug Scale as a Measure of Drug-related Anticholinergic Burden: Associations With Serum Anticholinergic Activity. J Clin Pharmacol. 2006;46(12):1481-6. PubMed PMID: 17101747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. AU - Carnahan,Ryan M, AU - Lund,Brian C, AU - Perry,Paul J, AU - Pollock,Bruce G, AU - Culp,Kennith R, PY - 2006/11/15/pubmed PY - 2007/2/27/medline PY - 2006/11/15/entrez SP - 1481 EP - 6 JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 46 IS - 12 N2 - Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long-term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R2 = .0947, P < .0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R2 = .0741, P < .0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/17101747/The_Anticholinergic_Drug_Scale_as_a_measure_of_drug_related_anticholinergic_burden:_associations_with_serum_anticholinergic_activity_ L2 - https://doi.org/10.1177/0091270006292126 DB - PRIME DP - Unbound Medicine ER -