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African American women have poor long-term survival following ischemic stroke.
Neurology. 2006 Nov 14; 67(9):1623-9.Neur

Abstract

OBJECTIVE

To determine racial and gender differences in long-term survival following ischemic stroke in a well-defined cohort of patients.

METHODS

We analyzed the prospectively collected data from a randomized, placebo-controlled trial in patients with ischemic stroke presenting within 3 hours of symptom onset. We determined the effect of race and gender on 1-year survival ascertained by serial follow-ups using Kaplan-Meier analysis. Multivariate analysis was performed adjusting for age, initial NIH Stroke Scale (NIHSS) score, use of thrombolysis, time to randomization, stroke etiology, and other cardiovascular risk factors.

RESULTS

Of the 547 patients with ischemic stroke, the 1-year survival (percentage +/- SE) for African American women (63 +/- 6%) was lower than white women (73 +/- 4%), African American men (79 +/- 4%), and white men (75 +/- 3%). Among the 209 patients younger than 65 years, the 1-year survival was prominently lower for African American women (66 +/- 8%) vs white women (87 +/- 5%), African American men (83 +/- 5%), and white men (89 +/- 3%). In the Cox proportional hazard analysis, African American women had a significantly higher rate of 1-year mortality (relative risk 2.1, 95% CI 1.2 to 3.5) after adjusting for all potential confounders except diabetes mellitus. After adjustment for diabetes mellitus, the difference became insignificant, although a 70% greater risk of 1-year mortality was still observed.

CONCLUSIONS

Compared with whites and men, African American women have a lower 1-year survival following ischemic stroke.

Authors+Show Affiliations

Epidemiological and Outcomes Research Division, Zeenat Qureshi Stroke Research Center. aiqureshi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17101894

Citation

Qureshi, Adnan I., et al. "African American Women Have Poor Long-term Survival Following Ischemic Stroke." Neurology, vol. 67, no. 9, 2006, pp. 1623-9.
Qureshi AI, Suri MF, Zhou J, et al. African American women have poor long-term survival following ischemic stroke. Neurology. 2006;67(9):1623-9.
Qureshi, A. I., Suri, M. F., Zhou, J., & Divani, A. A. (2006). African American women have poor long-term survival following ischemic stroke. Neurology, 67(9), 1623-9.
Qureshi AI, et al. African American Women Have Poor Long-term Survival Following Ischemic Stroke. Neurology. 2006 Nov 14;67(9):1623-9. PubMed PMID: 17101894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - African American women have poor long-term survival following ischemic stroke. AU - Qureshi,Adnan I, AU - Suri,M Fareed K, AU - Zhou,Jingying, AU - Divani,Afshin A, PY - 2006/11/15/pubmed PY - 2006/12/27/medline PY - 2006/11/15/entrez SP - 1623 EP - 9 JF - Neurology JO - Neurology VL - 67 IS - 9 N2 - OBJECTIVE: To determine racial and gender differences in long-term survival following ischemic stroke in a well-defined cohort of patients. METHODS: We analyzed the prospectively collected data from a randomized, placebo-controlled trial in patients with ischemic stroke presenting within 3 hours of symptom onset. We determined the effect of race and gender on 1-year survival ascertained by serial follow-ups using Kaplan-Meier analysis. Multivariate analysis was performed adjusting for age, initial NIH Stroke Scale (NIHSS) score, use of thrombolysis, time to randomization, stroke etiology, and other cardiovascular risk factors. RESULTS: Of the 547 patients with ischemic stroke, the 1-year survival (percentage +/- SE) for African American women (63 +/- 6%) was lower than white women (73 +/- 4%), African American men (79 +/- 4%), and white men (75 +/- 3%). Among the 209 patients younger than 65 years, the 1-year survival was prominently lower for African American women (66 +/- 8%) vs white women (87 +/- 5%), African American men (83 +/- 5%), and white men (89 +/- 3%). In the Cox proportional hazard analysis, African American women had a significantly higher rate of 1-year mortality (relative risk 2.1, 95% CI 1.2 to 3.5) after adjusting for all potential confounders except diabetes mellitus. After adjustment for diabetes mellitus, the difference became insignificant, although a 70% greater risk of 1-year mortality was still observed. CONCLUSIONS: Compared with whites and men, African American women have a lower 1-year survival following ischemic stroke. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17101894/African_American_women_have_poor_long_term_survival_following_ischemic_stroke_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17101894 DB - PRIME DP - Unbound Medicine ER -