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Modern aldol methods for the total synthesis of polyketides.
Angew Chem Int Ed Engl. 2006 Nov 20; 45(45):7506-25.AC

Abstract

The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods.

Authors+Show Affiliations

Schetter B
Chemisches Institut, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
Mahrwald R
No affiliation info available

MeSH

AldehydesAnti-Bacterial AgentsBoronCatalysisErythromycinMacrolidesMolecular StructureOrganometallic Compounds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17103481

Citation

Schetter, Bernd, and Rainer Mahrwald. "Modern Aldol Methods for the Total Synthesis of Polyketides." Angewandte Chemie (International Ed. in English), vol. 45, no. 45, 2006, pp. 7506-25.
Schetter B, Mahrwald R. Modern aldol methods for the total synthesis of polyketides. Angew Chem Int Ed Engl. 2006;45(45):7506-25.
Schetter, B., & Mahrwald, R. (2006). Modern aldol methods for the total synthesis of polyketides. Angewandte Chemie (International Ed. in English), 45(45), 7506-25.
Schetter B, Mahrwald R. Modern Aldol Methods for the Total Synthesis of Polyketides. Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7506-25. PubMed PMID: 17103481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modern aldol methods for the total synthesis of polyketides. AU - Schetter,Bernd, AU - Mahrwald,Rainer, PY - 2006/11/15/pubmed PY - 2007/1/25/medline PY - 2006/11/15/entrez SP - 7506 EP - 25 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 45 IS - 45 N2 - The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods. SN - 1433-7851 UR - https://www.unboundmedicine.com/medline/citation/17103481/Modern_aldol_methods_for_the_total_synthesis_of_polyketides_ L2 - https://doi.org/10.1002/anie.200602780 DB - PRIME DP - Unbound Medicine ER -