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Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
Br J Dermatol. 2006 Dec; 155(6):1256-61.BJ

Abstract

BACKGROUND

A reduction of symptoms of atopic dermatitis (AD) in small infants by the administration of Lactobacillus rhamnosus has been reported in a few studies. One study with older children and adolescents failed to show any effect.

OBJECTIVES

We conducted a prospective study to reassess the efficacy of orally administered L. rhamnosus strain GG (LGG) in infants with AD.

METHODS

In a randomized, double-blind, placebo-controlled study, 54 infants aged 1-55 months with moderate to severe AD were randomized to daily 10 x 10(9) colony-forming units of LGG or to placebo during an 8-week intervention phase. Emollients, class I-II topical corticosteroids and antihistamines were permitted.

RESULTS

The treatment with LGG was well tolerated. At the end of treatment there were no significant differences between the groups with respect to clinical symptoms (SCORAD, pruritus, sleep loss), the use of topical corticosteroids and antihistamines, immunological parameters, or health-related quality of life of the parents.

CONCLUSIONS

Our results could not confirm LGG as an effective treatment of AD in infancy.

Authors+Show Affiliations

Department of Dermatology, University of Kiel, Kiel, Germany. rfoelsterholst@dermatology.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17107398

Citation

Fölster-Holst, R, et al. "Prospective, Randomized Controlled Trial On Lactobacillus Rhamnosus in Infants With Moderate to Severe Atopic Dermatitis." The British Journal of Dermatology, vol. 155, no. 6, 2006, pp. 1256-61.
Fölster-Holst R, Müller F, Schnopp N, et al. Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. Br J Dermatol. 2006;155(6):1256-61.
Fölster-Holst, R., Müller, F., Schnopp, N., Abeck, D., Kreiselmaier, I., Lenz, T., von Rüden, U., Schrezenmeir, J., Christophers, E., & Weichenthal, M. (2006). Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. The British Journal of Dermatology, 155(6), 1256-61.
Fölster-Holst R, et al. Prospective, Randomized Controlled Trial On Lactobacillus Rhamnosus in Infants With Moderate to Severe Atopic Dermatitis. Br J Dermatol. 2006;155(6):1256-61. PubMed PMID: 17107398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. AU - Fölster-Holst,R, AU - Müller,F, AU - Schnopp,N, AU - Abeck,D, AU - Kreiselmaier,I, AU - Lenz,T, AU - von Rüden,U, AU - Schrezenmeir,J, AU - Christophers,E, AU - Weichenthal,M, PY - 2006/11/17/pubmed PY - 2007/5/9/medline PY - 2006/11/17/entrez SP - 1256 EP - 61 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 155 IS - 6 N2 - BACKGROUND: A reduction of symptoms of atopic dermatitis (AD) in small infants by the administration of Lactobacillus rhamnosus has been reported in a few studies. One study with older children and adolescents failed to show any effect. OBJECTIVES: We conducted a prospective study to reassess the efficacy of orally administered L. rhamnosus strain GG (LGG) in infants with AD. METHODS: In a randomized, double-blind, placebo-controlled study, 54 infants aged 1-55 months with moderate to severe AD were randomized to daily 10 x 10(9) colony-forming units of LGG or to placebo during an 8-week intervention phase. Emollients, class I-II topical corticosteroids and antihistamines were permitted. RESULTS: The treatment with LGG was well tolerated. At the end of treatment there were no significant differences between the groups with respect to clinical symptoms (SCORAD, pruritus, sleep loss), the use of topical corticosteroids and antihistamines, immunological parameters, or health-related quality of life of the parents. CONCLUSIONS: Our results could not confirm LGG as an effective treatment of AD in infancy. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17107398/Prospective_randomized_controlled_trial_on_Lactobacillus_rhamnosus_in_infants_with_moderate_to_severe_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-2133.2006.07558.x DB - PRIME DP - Unbound Medicine ER -