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The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study.
Stud Health Technol Inform. 2006; 123:3-8.SH

Abstract

Many studies have demonstrated the role of melatonin in the etiology of AIS. Previous studies have shown that there is no evidence of mutations in the melatonin receptor 1A gene in AIS patients. In this study, we have examined the role of melatonin receptor 1B in predisposition for AIS. Using haplotype block tagging technique, a set of tagging SNPs were defined for MTNR1B from the Han Chinese data of the International HapMap project. The association between the tagging of single nucleotide polymorphisms (tSNPs) in MTNR1B region and the occurrence of AIS was studied.

METHOD

473 AIS girls and 311 normal controls were recruited. The age range of the patients was between 10 and 18 years old. The maximum Cobb was recorded at latest follow-up in AIS patients. Three of five tSNPs were studied; they were all located within the coding region of the MTNR1B gene.

RESULTS

There was no significant difference in the genotype or allelic frequencies (AF) of the 3 tSNPs between AIS and controls. In a case-only analysis, no difference in curve severity in AIS patients was found among patients with different genotypes (by one-way ANOVA).

DISCUSSION

The 3 tSNPs showed no association with either the occurrence of AIS or the maximum Cobb angle within AIS girls. Further analysis of the remaining tSNPs within the regulatory region of the MTNR1B gene and other related genes in the melatonin signaling pathway may provide further information on the role of the melatonin in AIS girls.

Authors+Show Affiliations

The Affiliated Drum Town Hospital of Nanjing University Medical School, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17108395

Citation

Qiu, X S., et al. "The Role of Melatonin Receptor 1B Gene (MTNR1B) in Adolescent Idiopathic Scoliosis--a Genetic Association Study." Studies in Health Technology and Informatics, vol. 123, 2006, pp. 3-8.
Qiu XS, Tang NL, Yeung HY, et al. The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. Stud Health Technol Inform. 2006;123:3-8.
Qiu, X. S., Tang, N. L., Yeung, H. Y., Qiu, Y., Qin, L., Lee, K. M., & Cheng, J. C. (2006). The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. Studies in Health Technology and Informatics, 123, 3-8.
Qiu XS, et al. The Role of Melatonin Receptor 1B Gene (MTNR1B) in Adolescent Idiopathic Scoliosis--a Genetic Association Study. Stud Health Technol Inform. 2006;123:3-8. PubMed PMID: 17108395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. AU - Qiu,X S, AU - Tang,N L, AU - Yeung,H Y, AU - Qiu,Y, AU - Qin,L, AU - Lee,K M, AU - Cheng,J C Y, PY - 2006/11/17/pubmed PY - 2007/1/4/medline PY - 2006/11/17/entrez SP - 3 EP - 8 JF - Studies in health technology and informatics JO - Stud Health Technol Inform VL - 123 N2 - UNLABELLED: Many studies have demonstrated the role of melatonin in the etiology of AIS. Previous studies have shown that there is no evidence of mutations in the melatonin receptor 1A gene in AIS patients. In this study, we have examined the role of melatonin receptor 1B in predisposition for AIS. Using haplotype block tagging technique, a set of tagging SNPs were defined for MTNR1B from the Han Chinese data of the International HapMap project. The association between the tagging of single nucleotide polymorphisms (tSNPs) in MTNR1B region and the occurrence of AIS was studied. METHOD: 473 AIS girls and 311 normal controls were recruited. The age range of the patients was between 10 and 18 years old. The maximum Cobb was recorded at latest follow-up in AIS patients. Three of five tSNPs were studied; they were all located within the coding region of the MTNR1B gene. RESULTS: There was no significant difference in the genotype or allelic frequencies (AF) of the 3 tSNPs between AIS and controls. In a case-only analysis, no difference in curve severity in AIS patients was found among patients with different genotypes (by one-way ANOVA). DISCUSSION: The 3 tSNPs showed no association with either the occurrence of AIS or the maximum Cobb angle within AIS girls. Further analysis of the remaining tSNPs within the regulatory region of the MTNR1B gene and other related genes in the melatonin signaling pathway may provide further information on the role of the melatonin in AIS girls. SN - 0926-9630 UR - https://www.unboundmedicine.com/medline/citation/17108395/The_role_of_melatonin_receptor_1B_gene__MTNR1B__in_adolescent_idiopathic_scoliosis__a_genetic_association_study_ L2 - http://ebooks.iospress.nl/Extern/EnterMedLine.aspx?ISSN=0926-9630&Volume=123&SPage=3 DB - PRIME DP - Unbound Medicine ER -