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Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis.
Int Arch Allergy Immunol 2007; 142(3):211-8IA

Abstract

BACKGROUND

Atopic dermatitis (AD) is a chronic multifactorial allergic disease with unclear etiology. The antimicrobial human beta-defensin 1 is chemotactic for dendritic cells, which are important regulators of allergic immune responses. In an attempt to identify useful markers that could predict susceptibility to AD, we investigated single nucleotide polymorphisms (SNPs) of the beta-defensin 1 gene (DEFB1) with potential functional consequences.

METHODS

Four SNPs of the DEFB1 gene were genotyped either by real-time polymerase chain reaction or polymerase chain reaction-restriction fragment length polymorphisms in 59 patients with AD and 151 controls from the Mexican population. Correlation analyses were carried out between genetic, environmental and clinical variables in AD patients.

RESULTS

The genotypes associated with susceptibility to AD and no other allergy were 692 GG (OR = 3.21, 95% CI 1.37-7.34) and 1654 AA (OR = 17.37, 95% CI 1.62-860.83). The allele 668 C is a risk factor for AD (OR = 2.23, 95% CI 1.22-4.01) and the allele A in site 1836 correlates with earlier age at onset (Spearman's rho = 0.232; p = 0.03). The prolonged duration of breastfeeding correlates with earlier age at onset as well as with the severity of AD.

CONCLUSIONS

The DEFB1 gene is probably involved in the incidence and development of AD, but additional functional studies will be necessary to understand the biological role of these SNPs.

Authors+Show Affiliations

PhD Program in Human Genetics, Universidad de Guadalajara, Guadalajara, Jalisco, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17108702

Citation

Prado-Montes de Oca, Ernesto, et al. "Association of Beta-defensin 1 Single Nucleotide Polymorphisms With Atopic Dermatitis." International Archives of Allergy and Immunology, vol. 142, no. 3, 2007, pp. 211-8.
Prado-Montes de Oca E, García-Vargas A, Lozano-Inocencio R, et al. Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis. Int Arch Allergy Immunol. 2007;142(3):211-8.
Prado-Montes de Oca, E., García-Vargas, A., Lozano-Inocencio, R., Gallegos-Arreola, M. P., Sandoval-Ramírez, L., Dávalos-Rodríguez, N. O., & Figuera, L. E. (2007). Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis. International Archives of Allergy and Immunology, 142(3), pp. 211-8.
Prado-Montes de Oca E, et al. Association of Beta-defensin 1 Single Nucleotide Polymorphisms With Atopic Dermatitis. Int Arch Allergy Immunol. 2007;142(3):211-8. PubMed PMID: 17108702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis. AU - Prado-Montes de Oca,Ernesto, AU - García-Vargas,Alejandro, AU - Lozano-Inocencio,Reymundo, AU - Gallegos-Arreola,Martha Patricia, AU - Sandoval-Ramírez,Lucila, AU - Dávalos-Rodríguez,Nory Omara, AU - Figuera,Luis Eduardo, Y1 - 2006/11/14/ PY - 2006/02/13/received PY - 2006/08/03/accepted PY - 2006/11/17/pubmed PY - 2007/3/30/medline PY - 2006/11/17/entrez SP - 211 EP - 8 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 142 IS - 3 N2 - BACKGROUND: Atopic dermatitis (AD) is a chronic multifactorial allergic disease with unclear etiology. The antimicrobial human beta-defensin 1 is chemotactic for dendritic cells, which are important regulators of allergic immune responses. In an attempt to identify useful markers that could predict susceptibility to AD, we investigated single nucleotide polymorphisms (SNPs) of the beta-defensin 1 gene (DEFB1) with potential functional consequences. METHODS: Four SNPs of the DEFB1 gene were genotyped either by real-time polymerase chain reaction or polymerase chain reaction-restriction fragment length polymorphisms in 59 patients with AD and 151 controls from the Mexican population. Correlation analyses were carried out between genetic, environmental and clinical variables in AD patients. RESULTS: The genotypes associated with susceptibility to AD and no other allergy were 692 GG (OR = 3.21, 95% CI 1.37-7.34) and 1654 AA (OR = 17.37, 95% CI 1.62-860.83). The allele 668 C is a risk factor for AD (OR = 2.23, 95% CI 1.22-4.01) and the allele A in site 1836 correlates with earlier age at onset (Spearman's rho = 0.232; p = 0.03). The prolonged duration of breastfeeding correlates with earlier age at onset as well as with the severity of AD. CONCLUSIONS: The DEFB1 gene is probably involved in the incidence and development of AD, but additional functional studies will be necessary to understand the biological role of these SNPs. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/17108702/Association_of_beta_defensin_1_single_nucleotide_polymorphisms_with_atopic_dermatitis_ L2 - https://www.karger.com?DOI=10.1159/000097023 DB - PRIME DP - Unbound Medicine ER -