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Adolescent dietary phytoestrogen intake and breast cancer risk (Canada).

Abstract

OBJECTIVE

It has been suggested that dietary phytoestrogen intake during adolescence may reduce the risk of developing breast cancer. This population-based case-control study evaluated the association between adolescent dietary phytoestrogen intake and adult breast cancer risk among women in Ontario, Canada.

METHODS

Pathology-confirmed, population-based breast cancer cases, aged 25-74 years, diagnosed between June 2002 and April 2003, were identified using the Ontario Cancer Registry. Population-based controls were recruited, and matched to cases within 5-year age groups. Adolescent phytoestrogen intake was obtained using a brief food frequency questionnaire (n = 3,024 cases, n = 3,420 controls). Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

Higher phytoestrogen intake (both isoflavones and lignans) during adolescence was associated with a reduced breast cancer risk, and a monotonic trend was observed from the lowest to the highest quartile (OR [Q2] = 0.91, 95% CI 0.79-1.04, OR[Q3] = 0.86, 95% CI 0.75-0.98, and OR[Q4] = 0.71, 95% CI 0.62-0.82, p-trend < 0.001).

CONCLUSION

Adolescent dietary phytoestrogen intake may be associated with a decreased risk of adult breast cancer. If verified, this finding has important implications with regard to breast cancer prevention since diet is a potentially modifiable factor.

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  • Authors+Show Affiliations

    ,

    Department of Public Health Sciences, University of Toronto, Toronto, Ont, Canada.

    , , ,

    Source

    Cancer causes & control : CCC 17:10 2006 Dec pg 1253-61

    MeSH

    Adolescent
    Breast Neoplasms
    Canada
    Case-Control Studies
    Diet
    Disease Susceptibility
    Female
    Humans
    Odds Ratio
    Phytoestrogens
    Registries
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17111256

    Citation

    Thanos, Joanne, et al. "Adolescent Dietary Phytoestrogen Intake and Breast Cancer Risk (Canada)." Cancer Causes & Control : CCC, vol. 17, no. 10, 2006, pp. 1253-61.
    Thanos J, Cotterchio M, Boucher BA, et al. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control. 2006;17(10):1253-61.
    Thanos, J., Cotterchio, M., Boucher, B. A., Kreiger, N., & Thompson, L. U. (2006). Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes & Control : CCC, 17(10), pp. 1253-61.
    Thanos J, et al. Adolescent Dietary Phytoestrogen Intake and Breast Cancer Risk (Canada). Cancer Causes Control. 2006;17(10):1253-61. PubMed PMID: 17111256.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). AU - Thanos,Joanne, AU - Cotterchio,Michelle, AU - Boucher,Beatrice A, AU - Kreiger,Nancy, AU - Thompson,Lilian U, PY - 2006/07/12/accepted PY - 2006/02/03/revised PY - 2006/11/18/pubmed PY - 2007/2/28/medline PY - 2006/11/18/entrez SP - 1253 EP - 61 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 17 IS - 10 N2 - OBJECTIVE: It has been suggested that dietary phytoestrogen intake during adolescence may reduce the risk of developing breast cancer. This population-based case-control study evaluated the association between adolescent dietary phytoestrogen intake and adult breast cancer risk among women in Ontario, Canada. METHODS: Pathology-confirmed, population-based breast cancer cases, aged 25-74 years, diagnosed between June 2002 and April 2003, were identified using the Ontario Cancer Registry. Population-based controls were recruited, and matched to cases within 5-year age groups. Adolescent phytoestrogen intake was obtained using a brief food frequency questionnaire (n = 3,024 cases, n = 3,420 controls). Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Higher phytoestrogen intake (both isoflavones and lignans) during adolescence was associated with a reduced breast cancer risk, and a monotonic trend was observed from the lowest to the highest quartile (OR [Q2] = 0.91, 95% CI 0.79-1.04, OR[Q3] = 0.86, 95% CI 0.75-0.98, and OR[Q4] = 0.71, 95% CI 0.62-0.82, p-trend < 0.001). CONCLUSION: Adolescent dietary phytoestrogen intake may be associated with a decreased risk of adult breast cancer. If verified, this finding has important implications with regard to breast cancer prevention since diet is a potentially modifiable factor. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17111256/Adolescent_dietary_phytoestrogen_intake_and_breast_cancer_risk__Canada__ L2 - https://doi.org/10.1007/s10552-006-0062-2 DB - PRIME DP - Unbound Medicine ER -