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[A new triterpenoid saponin from stems of Akebia trifoliata].
Yao Xue Xue Bao. 2006 Sep; 41(9):835-9.YX

Abstract

AIM

To study the chemical constituents of the stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd.

METHODS

The compounds were isolated and purified by recrystallization and chromatography on silica gel and ODS column. Their structures were elucidated on the basis of physicochemical properties and spectral analysis.

RESULTS

Six compounds were identified as 2 alpha, 3 beta,23-trihydroxyolean-12-en-28-oic acid O-beta-D-xylopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (I), 2 alpha, 3 beta, 23-trihydroxyurs-12-en-28-oic acid O-beta-D-xylopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (II), 2 alpha, 3 beta, 23-trihydroxyolean-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (III), 2alpha, 3beta, 23-trihydroxyurs-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (IV), 2 alpha, 3 beta, 23-trihydroxyolean-12-en-28-oic acid O-beta-D-glucopyranosyl ester (V), 2 alpha, 3 alpha, 23-trihydroxyurs-12-en-28-oic acid O-beta-D-glucopyranosyl ester (VI).

CONCLUSION

Compound II, named mutongsaponin C, is a new triterpenoid saponin and others were isolated from the stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd for the first time.

Authors+Show Affiliations

Gao HM
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wang ZM
No affiliation info available

MeSH

Chromatography, GelCrystallizationMagnoliopsidaMolecular StructurePlant StemsPlants, MedicinalSaponinsSilica GelSilicon DioxideTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17111829

Citation

Gao, Hui-min, and Zhi-min Wang. "[A New Triterpenoid Saponin From Stems of Akebia Trifoliata]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 41, no. 9, 2006, pp. 835-9.
Gao HM, Wang ZM. [A new triterpenoid saponin from stems of Akebia trifoliata]. Yao Xue Xue Bao. 2006;41(9):835-9.
Gao, H. M., & Wang, Z. M. (2006). [A new triterpenoid saponin from stems of Akebia trifoliata]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 41(9), 835-9.
Gao HM, Wang ZM. [A New Triterpenoid Saponin From Stems of Akebia Trifoliata]. Yao Xue Xue Bao. 2006;41(9):835-9. PubMed PMID: 17111829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A new triterpenoid saponin from stems of Akebia trifoliata]. AU - Gao,Hui-min, AU - Wang,Zhi-min, PY - 2006/11/23/pubmed PY - 2008/2/12/medline PY - 2006/11/23/entrez SP - 835 EP - 9 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 41 IS - 9 N2 - AIM: To study the chemical constituents of the stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd. METHODS: The compounds were isolated and purified by recrystallization and chromatography on silica gel and ODS column. Their structures were elucidated on the basis of physicochemical properties and spectral analysis. RESULTS: Six compounds were identified as 2 alpha, 3 beta,23-trihydroxyolean-12-en-28-oic acid O-beta-D-xylopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (I), 2 alpha, 3 beta, 23-trihydroxyurs-12-en-28-oic acid O-beta-D-xylopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (II), 2 alpha, 3 beta, 23-trihydroxyolean-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (III), 2alpha, 3beta, 23-trihydroxyurs-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1 --> 4)-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (IV), 2 alpha, 3 beta, 23-trihydroxyolean-12-en-28-oic acid O-beta-D-glucopyranosyl ester (V), 2 alpha, 3 alpha, 23-trihydroxyurs-12-en-28-oic acid O-beta-D-glucopyranosyl ester (VI). CONCLUSION: Compound II, named mutongsaponin C, is a new triterpenoid saponin and others were isolated from the stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd for the first time. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/17111829/[A_new_triterpenoid_saponin_from_stems_of_Akebia_trifoliata]_ DB - PRIME DP - Unbound Medicine ER -