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Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration.
Pharmacol Biochem Behav 2006; 85(2):454-63PB

Abstract

The combined use of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') with methamphetamine (METH) by recreational drug users is of particular concern due to their similar pharmacological and toxic profiles. In the current study we sought to elucidate why combining these particular drugs is such a popular choice among party-drug users. This was investigated through characterisation of the possible interactive effects of MDMA on METH intravenous self-administration. The first experiment involved characterisation of the METH dose-response curve for intravenous self-administration. Male Hooded-Wistar rats were trained to self-administer intravenous METH (0.01-0.3 mg/kg/infusion) and an inverted-U dose-response curve was obtained. In Experiment 2, a second squad of rats self-administered 0.01, 0.03 or 0.1 mg/kg/infusion METH and had small amounts of MDMA (0.001-0.03 mg/kg) then introduced into the infusion solution. Addition of MDMA to the METH infusion solution resulted in a dose independent reduction in responding. In Experiment 3, a third squad of rats was treated 20 min pre-session with an intraperitoneal injection of saline, 1.25 or 2.5 mg/kg of MDMA or METH to evaluate whether the reduction in responding evident in Experiment 2 was due to an MDMA-induced decrease in locomotor activity. Pre-treatment with intraperitoneal MDMA or METH had no effect on METH self-administration nor activity. We hypothesise that the reduction in METH self-administration caused by MDMA may reflect inhibitory effects of MDMA-induced 5-HT release on dopaminergic mechanisms.

Authors+Show Affiliations

School of Psychology A16, University of Sydney, NSW 2006, Australia. kclemens@psy.unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17112571

Citation

Clemens, Kelly J., et al. "Intravenous Methamphetamine Self-administration in Rats: Effects of Intravenous or Intraperitoneal MDMA Co-administration." Pharmacology, Biochemistry, and Behavior, vol. 85, no. 2, 2006, pp. 454-63.
Clemens KJ, Cornish JL, Hunt GE, et al. Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration. Pharmacol Biochem Behav. 2006;85(2):454-63.
Clemens, K. J., Cornish, J. L., Hunt, G. E., & McGregor, I. S. (2006). Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration. Pharmacology, Biochemistry, and Behavior, 85(2), pp. 454-63.
Clemens KJ, et al. Intravenous Methamphetamine Self-administration in Rats: Effects of Intravenous or Intraperitoneal MDMA Co-administration. Pharmacol Biochem Behav. 2006;85(2):454-63. PubMed PMID: 17112571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration. AU - Clemens,Kelly J, AU - Cornish,Jennifer L, AU - Hunt,Glenn E, AU - McGregor,Iain S, Y1 - 2006/11/15/ PY - 2005/10/12/received PY - 2006/09/08/revised PY - 2006/09/27/accepted PY - 2006/11/23/pubmed PY - 2007/2/21/medline PY - 2006/11/23/entrez SP - 454 EP - 63 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 85 IS - 2 N2 - The combined use of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') with methamphetamine (METH) by recreational drug users is of particular concern due to their similar pharmacological and toxic profiles. In the current study we sought to elucidate why combining these particular drugs is such a popular choice among party-drug users. This was investigated through characterisation of the possible interactive effects of MDMA on METH intravenous self-administration. The first experiment involved characterisation of the METH dose-response curve for intravenous self-administration. Male Hooded-Wistar rats were trained to self-administer intravenous METH (0.01-0.3 mg/kg/infusion) and an inverted-U dose-response curve was obtained. In Experiment 2, a second squad of rats self-administered 0.01, 0.03 or 0.1 mg/kg/infusion METH and had small amounts of MDMA (0.001-0.03 mg/kg) then introduced into the infusion solution. Addition of MDMA to the METH infusion solution resulted in a dose independent reduction in responding. In Experiment 3, a third squad of rats was treated 20 min pre-session with an intraperitoneal injection of saline, 1.25 or 2.5 mg/kg of MDMA or METH to evaluate whether the reduction in responding evident in Experiment 2 was due to an MDMA-induced decrease in locomotor activity. Pre-treatment with intraperitoneal MDMA or METH had no effect on METH self-administration nor activity. We hypothesise that the reduction in METH self-administration caused by MDMA may reflect inhibitory effects of MDMA-induced 5-HT release on dopaminergic mechanisms. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/17112571/Intravenous_methamphetamine_self_administration_in_rats:_effects_of_intravenous_or_intraperitoneal_MDMA_co_administration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(06)00317-0 DB - PRIME DP - Unbound Medicine ER -