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Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo.
J Ethnopharmacol. 2007 Apr 04; 110(3):483-9.JE

Abstract

Selaginella tamariscina is a traditional Chinese herb for the therapy of chronic trachitis and has been approved some anti-tumor activity. However, the anti-metastasis effects of Selaginella tamariscina in the lung cancer have not been understood clearly. The objectives of study were to investigate the effects of the Selaginella tamariscina extracts (STE) on the invasion and motility of highly metastatic A549 and Lewis lung carcinoma (LLC) cells. To further investigate the precise involvement of STE in tumor metastasis, A549 and LLC cells were treated with STE at various concentrations (0-100 microg/mL) for a specified period. The results from zymography showed that a STE treatment decreased (p<0.05) the expressions of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator (u-PA) in a dose-dependent manner in the A549 and LLC cell. Meanwhile, their endogenous inhibitors, which are tissue inhibitor of metalloproteinase-2 (TIMP-2) and plasminogen activator inhibitor-1 (PAI-1), were increased in the A549 cell. Furthermore, the inhibitory effect of STE on the growth and metastasis of LLC cells in vivo was also proven. These results demonstrated that STE could be a candidate antimetastatic agent against lung cancer.

Authors+Show Affiliations

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17113737

Citation

Yang, Shun Fa, et al. "Antimetastatic Activities of Selaginella Tamariscina (Beauv.) On Lung Cancer Cells in Vitro and in Vivo." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 483-9.
Yang SF, Chu SC, Liu SJ, et al. Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. J Ethnopharmacol. 2007;110(3):483-9.
Yang, S. F., Chu, S. C., Liu, S. J., Chen, Y. C., Chang, Y. Z., & Hsieh, Y. S. (2007). Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. Journal of Ethnopharmacology, 110(3), 483-9.
Yang SF, et al. Antimetastatic Activities of Selaginella Tamariscina (Beauv.) On Lung Cancer Cells in Vitro and in Vivo. J Ethnopharmacol. 2007 Apr 4;110(3):483-9. PubMed PMID: 17113737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. AU - Yang,Shun Fa, AU - Chu,Shu Chen, AU - Liu,Shang Jung, AU - Chen,Yi Chen, AU - Chang,Yan Zin, AU - Hsieh,Yih Shou, Y1 - 2006/10/20/ PY - 2006/05/18/received PY - 2006/09/27/revised PY - 2006/10/12/accepted PY - 2006/11/23/pubmed PY - 2007/6/15/medline PY - 2006/11/23/entrez SP - 483 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - Selaginella tamariscina is a traditional Chinese herb for the therapy of chronic trachitis and has been approved some anti-tumor activity. However, the anti-metastasis effects of Selaginella tamariscina in the lung cancer have not been understood clearly. The objectives of study were to investigate the effects of the Selaginella tamariscina extracts (STE) on the invasion and motility of highly metastatic A549 and Lewis lung carcinoma (LLC) cells. To further investigate the precise involvement of STE in tumor metastasis, A549 and LLC cells were treated with STE at various concentrations (0-100 microg/mL) for a specified period. The results from zymography showed that a STE treatment decreased (p<0.05) the expressions of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator (u-PA) in a dose-dependent manner in the A549 and LLC cell. Meanwhile, their endogenous inhibitors, which are tissue inhibitor of metalloproteinase-2 (TIMP-2) and plasminogen activator inhibitor-1 (PAI-1), were increased in the A549 cell. Furthermore, the inhibitory effect of STE on the growth and metastasis of LLC cells in vivo was also proven. These results demonstrated that STE could be a candidate antimetastatic agent against lung cancer. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17113737/Antimetastatic_activities_of_Selaginella_tamariscina__Beauv___on_lung_cancer_cells_in_vitro_and_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00525-3 DB - PRIME DP - Unbound Medicine ER -