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The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection.
J Ethnopharmacol. 2007 Apr 04; 110(3):555-8.JE

Abstract

Phyllanthus urinaria Linnea (Euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. Previously, the acetone extract from Phyllanthus urinaria was found to inhibit herpes simplex virus (HSV) infection. In this study, geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose (1346TOGDG), both of which were isolated from the acetone extract of Phyllanthus urinaria, were examined for their activity against HSV-1 and HSV-2 in vitro. Results showed that geraniin actively suppressed HSV-2 infection, whereas 1346TOGDG effectively inhibited HSV-1 infection. The 50% inhibitory concentration (IC(50)) was 18.4+/-2.0 microM for geraniin against HSV-2 infection, and 19.2+/-4.0 microM for 1346TOGDG against HSV-1. No toxic effect towards the host cell was observed at the antiviral concentrations. In conclusion, geraniin and 1346TOGDG were found to inhibit HSV-1 and HSV-2 multiplication at different magnitudes of potency.

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Authors+Show Affiliations

Yang CM
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan.
Cheng HY
No affiliation info available
Lin TC
No affiliation info available
Chiang LC
No affiliation info available
Lin CC
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsDose-Response Relationship, DrugGallic AcidGlucosidesHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanHydrolyzable TanninsKidneyMedicine, East Asian TraditionalMonosaccharidesPhyllanthusPhytotherapyPlant ExtractsPlants, MedicinalVero Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17113739

Citation

Yang, Chien-Min, et al. "The in Vitro Activity of Geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose Isolated From Phyllanthus Urinaria Against Herpes Simplex Virus Type 1 and Type 2 Infection." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 555-8.
Yang CM, Cheng HY, Lin TC, et al. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. J Ethnopharmacol. 2007;110(3):555-8.
Yang, C. M., Cheng, H. Y., Lin, T. C., Chiang, L. C., & Lin, C. C. (2007). The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. Journal of Ethnopharmacology, 110(3), 555-8.
Yang CM, et al. The in Vitro Activity of Geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose Isolated From Phyllanthus Urinaria Against Herpes Simplex Virus Type 1 and Type 2 Infection. J Ethnopharmacol. 2007 Apr 4;110(3):555-8. PubMed PMID: 17113739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. AU - Yang,Chien-Min, AU - Cheng,Hua-Yew, AU - Lin,Ta-Chen, AU - Chiang,Lien-Chai, AU - Lin,Chun-Ching, Y1 - 2006/10/13/ PY - 2005/11/24/received PY - 2006/08/17/revised PY - 2006/09/23/accepted PY - 2006/11/23/pubmed PY - 2007/6/15/medline PY - 2006/11/23/entrez SP - 555 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - Phyllanthus urinaria Linnea (Euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. Previously, the acetone extract from Phyllanthus urinaria was found to inhibit herpes simplex virus (HSV) infection. In this study, geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose (1346TOGDG), both of which were isolated from the acetone extract of Phyllanthus urinaria, were examined for their activity against HSV-1 and HSV-2 in vitro. Results showed that geraniin actively suppressed HSV-2 infection, whereas 1346TOGDG effectively inhibited HSV-1 infection. The 50% inhibitory concentration (IC(50)) was 18.4+/-2.0 microM for geraniin against HSV-2 infection, and 19.2+/-4.0 microM for 1346TOGDG against HSV-1. No toxic effect towards the host cell was observed at the antiviral concentrations. In conclusion, geraniin and 1346TOGDG were found to inhibit HSV-1 and HSV-2 multiplication at different magnitudes of potency. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17113739/The_in_vitro_activity_of_geraniin_and_1346_tetra_O_galloyl_beta_D_glucose_isolated_from_Phyllanthus_urinaria_against_herpes_simplex_virus_type_1_and_type_2_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00516-2 DB - PRIME DP - Unbound Medicine ER -