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Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease.
Brain Res Bull. 2006 Dec 11; 71(1-3):149-54.BR

Abstract

This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change=0.93+/-0.62; Wilcoxon: p=0.0002, n=13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.

Authors+Show Affiliations

Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Milano, Italy. alberto.priori@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17113940

Citation

Priori, A, et al. "Low-frequency Subthalamic Oscillations Increase After Deep Brain Stimulation in Parkinson's Disease." Brain Research Bulletin, vol. 71, no. 1-3, 2006, pp. 149-54.
Priori A, Ardolino G, Marceglia S, et al. Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease. Brain Res Bull. 2006;71(1-3):149-54.
Priori, A., Ardolino, G., Marceglia, S., Mrakic-Sposta, S., Locatelli, M., Tamma, F., Rossi, L., & Foffani, G. (2006). Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease. Brain Research Bulletin, 71(1-3), 149-54.
Priori A, et al. Low-frequency Subthalamic Oscillations Increase After Deep Brain Stimulation in Parkinson's Disease. Brain Res Bull. 2006 Dec 11;71(1-3):149-54. PubMed PMID: 17113940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease. AU - Priori,A, AU - Ardolino,G, AU - Marceglia,S, AU - Mrakic-Sposta,S, AU - Locatelli,M, AU - Tamma,F, AU - Rossi,L, AU - Foffani,G, Y1 - 2006/09/20/ PY - 2006/06/24/received PY - 2006/08/09/revised PY - 2006/08/18/accepted PY - 2006/11/23/pubmed PY - 2007/2/3/medline PY - 2006/11/23/entrez SP - 149 EP - 54 JF - Brain research bulletin JO - Brain Res Bull VL - 71 IS - 1-3 N2 - This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change=0.93+/-0.62; Wilcoxon: p=0.0002, n=13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/17113940/Low_frequency_subthalamic_oscillations_increase_after_deep_brain_stimulation_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(06)00255-3 DB - PRIME DP - Unbound Medicine ER -