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Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms?

Abstract

BACKGROUND

The Rome criteria serve as gold standard for establishing a diagnosis of irritable bowel syndrome (IBS), but only represent a cluster of symptoms. On the other hand, measurement of colonic transit time (CTT) with radiopaque markers is a solid and more objective method to quantify functional abnormalities. The goal of this study was to investigate whether the IBS symptoms, as defined in the Rome II criteria, correspond to objective physiological parameters, i.e. CCTs.

METHODS

The study enrolled 148 healthy control subjects and 1385 consecutive IBS patients. Transit times were measured for the whole rectocolon (overall CTT) and for 3 segments (right colon, left colon, rectosigmoid area); segmental distribution of markers and diffusion coefficients were also assessed. In order to analyze homogeneous groups, we restricted analysis to subjects with "normal" CTT (< or =70 hours).

RESULTS

Six hundred forty four IBS patients (46%) and 14 control subjects (9%) had CTT >70 h and were eliminated. In subjects with CTT < or =70 h, CTT did not follow a normal (Gaussian) distribution. We identified 3 different CTT clusters in healthy controls and 4 clusters in IBS patients. Even if CTT was not significantly different between clusters, each cluster was characterized by a specific pattern of segmental colonic transit. There was a marked gender difference: women had longer overall CTT values than men, both in control and IBS patient groups (p<0.001). However, female IBS patients had significantly shorter colorectal transit times than female controls (p<0.001), as well as faster transit than in men through the left colon and rectosigmoid area. There were no significant differences in transit time between male IBS patients and male controls with the exception of a faster rectal transit in IBS patients (p<0.01). There was no association between segmental colonic transit values and sign or symptoms comprising the Rome II criteria.

CONCLUSIONS

In subjects with CTT < or =70 h, CTT does not follow a normal distribution but is clustered in subgroups that can be distinguished only by measuring segmental colonic transit. Within these subgroups, there is a marked difference in transit times between IBS patients and normal subjects, suggesting that IBS patients with "normal" CTT are not "normal". The Rome II criteria do not reflect differences in segmental transit times in IBS patients with "normal" CTT. We therefore propose to evaluate segmental transit times in IBS patients with "normal" CTT, before and after treatment, in order to correctly interpretate variations in signs and symptoms. These findings have important implications in evaluating the effect of drugs on bowel function and should help define better inclusion criteria for studies evaluating new drugs for the treatment of IBS.

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  • Authors+Show Affiliations

    ,

    Digestive Physiology Laboratory, Broussais Hospital University of Paris V, 96 Rue Didot, 75014, Paris, France. michel.bouchoucha@brs.aphp.fr

    , , , ,

    Source

    Techniques in coloproctology 10:4 2006 Dec pg 287-96

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Cluster Analysis
    Colon
    Female
    Gastrointestinal Transit
    Humans
    Irritable Bowel Syndrome
    Kinetics
    Male
    Middle Aged
    Sex Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17115321

    Citation

    Bouchoucha, M, et al. "Different Segmental Transit Times in Patients With Irritable Bowel Syndrome and "normal" Colonic Transit Time: Is There a Correlation With Symptoms?" Techniques in Coloproctology, vol. 10, no. 4, 2006, pp. 287-96.
    Bouchoucha M, Devroede G, Dorval E, et al. Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms? Tech Coloproctol. 2006;10(4):287-96.
    Bouchoucha, M., Devroede, G., Dorval, E., Faye, A., Arhan, P., & Arsac, M. (2006). Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms? Techniques in Coloproctology, 10(4), pp. 287-96.
    Bouchoucha M, et al. Different Segmental Transit Times in Patients With Irritable Bowel Syndrome and "normal" Colonic Transit Time: Is There a Correlation With Symptoms. Tech Coloproctol. 2006;10(4):287-96. PubMed PMID: 17115321.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Different segmental transit times in patients with irritable bowel syndrome and "normal" colonic transit time: is there a correlation with symptoms? AU - Bouchoucha,M, AU - Devroede,G, AU - Dorval,E, AU - Faye,A, AU - Arhan,P, AU - Arsac,M, Y1 - 2006/11/27/ PY - 2005/05/20/received PY - 2006/04/16/accepted PY - 2006/11/23/pubmed PY - 2007/3/7/medline PY - 2006/11/23/entrez SP - 287 EP - 96 JF - Techniques in coloproctology JO - Tech Coloproctol VL - 10 IS - 4 N2 - BACKGROUND: The Rome criteria serve as gold standard for establishing a diagnosis of irritable bowel syndrome (IBS), but only represent a cluster of symptoms. On the other hand, measurement of colonic transit time (CTT) with radiopaque markers is a solid and more objective method to quantify functional abnormalities. The goal of this study was to investigate whether the IBS symptoms, as defined in the Rome II criteria, correspond to objective physiological parameters, i.e. CCTs. METHODS: The study enrolled 148 healthy control subjects and 1385 consecutive IBS patients. Transit times were measured for the whole rectocolon (overall CTT) and for 3 segments (right colon, left colon, rectosigmoid area); segmental distribution of markers and diffusion coefficients were also assessed. In order to analyze homogeneous groups, we restricted analysis to subjects with "normal" CTT (< or =70 hours). RESULTS: Six hundred forty four IBS patients (46%) and 14 control subjects (9%) had CTT >70 h and were eliminated. In subjects with CTT < or =70 h, CTT did not follow a normal (Gaussian) distribution. We identified 3 different CTT clusters in healthy controls and 4 clusters in IBS patients. Even if CTT was not significantly different between clusters, each cluster was characterized by a specific pattern of segmental colonic transit. There was a marked gender difference: women had longer overall CTT values than men, both in control and IBS patient groups (p<0.001). However, female IBS patients had significantly shorter colorectal transit times than female controls (p<0.001), as well as faster transit than in men through the left colon and rectosigmoid area. There were no significant differences in transit time between male IBS patients and male controls with the exception of a faster rectal transit in IBS patients (p<0.01). There was no association between segmental colonic transit values and sign or symptoms comprising the Rome II criteria. CONCLUSIONS: In subjects with CTT < or =70 h, CTT does not follow a normal distribution but is clustered in subgroups that can be distinguished only by measuring segmental colonic transit. Within these subgroups, there is a marked difference in transit times between IBS patients and normal subjects, suggesting that IBS patients with "normal" CTT are not "normal". The Rome II criteria do not reflect differences in segmental transit times in IBS patients with "normal" CTT. We therefore propose to evaluate segmental transit times in IBS patients with "normal" CTT, before and after treatment, in order to correctly interpretate variations in signs and symptoms. These findings have important implications in evaluating the effect of drugs on bowel function and should help define better inclusion criteria for studies evaluating new drugs for the treatment of IBS. SN - 1123-6337 UR - https://www.unboundmedicine.com/medline/citation/17115321/Different_segmental_transit_times_in_patients_with_irritable_bowel_syndrome_and_ L2 - https://dx.doi.org/10.1007/s10151-006-0295-9 DB - PRIME DP - Unbound Medicine ER -