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Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10).
Diabet Med 2006; 23(12):1344-9DM

Abstract

AIM

Individuals with diabetes and prediabetes are at risk of vascular injury. However, the exact mechanisms are unclear. The mitochondria mobile electron carrier coenzyme Q(10) (CoQ(10)) is a potent lipophilic antioxidant. We hypothesize that oxidative stress, detectable as changes in plasma CoQ(10) concentrations and composition, plays an important role in vascular disease in diabetes.

METHODS

We measured plasma CoQ(10) concentrations (including reduced ubiquinol and oxidized ubiquinone subfractions) in 60 subjects with normal glucose tolerance [NGT; fasting plasma glucose (FPG) < 5.5 mmol/l], 63 with impaired fasting glucose (IFG; FPG 5.6-6.9 mmol/l) and 69 with Type 2 diabetes (DM; FPG > 6.9 mmol/l).

RESULTS

In men and women, the total CoQ(10)/total cholesterol ratio was reduced in DM (mean +/-sd) [male (M) 0.09 +/- 0.04; female (F) 0.07 +/- 0.04] compared with NGT (0.29 +/- 0.08; 0.21 +/- 0.07) and IFG (0.27 +/- 0.07; 0.23 +/- 0.07) (DM vs. NGT and IFG P = 0.001). A stepwise reduction in the plasma ubiquinol fraction (ubiquinol/total CoQ10) was observed from NGT (M 0.93 +/- 0.06; F 0.95 +/- 0.06) compared with IFG (0.43 +/- 0.25; 0.41 +/- 0.15) and DM (0.24 +/- 0.11; F 0.29 +/- 0.16) (DM vs. IFG vs. NGT P = 0.001). In contrast, the plasma ubiquinone/ubiquinol ratio increased from NGT (M 0.08 +/- 0.07, F 0.06 +/- 0.08) to IFG (2.14 +/- 1.84, 1.75 +/- 1.04) to DM (4.77 +/- 4.88, 3.81 +/- 3.71) (DM vs. IFG vs. NGT P = 0.001). These differences remained after adjusting for age, body mass index and FPG.

CONCLUSIONS

The change in CoQ(10) with increasing FPG concentration suggests an increase in oxidative burden, already evident in the prediabetic IFG individuals. This increase in oxidative stress might contribute to the increased risk of vascular disease.

Authors+Show Affiliations

Department of Medicine, Alexandra Hospital, Singapore 159964, Republic of Singapore. su_chi_lim@alexhosp.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17116186

Citation

Lim, S C., et al. "Oxidative Burden in Prediabetic and Diabetic Individuals: Evidence From Plasma Coenzyme Q(10)." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 23, no. 12, 2006, pp. 1344-9.
Lim SC, Tan HH, Goh SK, et al. Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10). Diabet Med. 2006;23(12):1344-9.
Lim, S. C., Tan, H. H., Goh, S. K., Subramaniam, T., Sum, C. F., Tan, I. K., ... Ong, C. N. (2006). Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10). Diabetic Medicine : a Journal of the British Diabetic Association, 23(12), pp. 1344-9.
Lim SC, et al. Oxidative Burden in Prediabetic and Diabetic Individuals: Evidence From Plasma Coenzyme Q(10). Diabet Med. 2006;23(12):1344-9. PubMed PMID: 17116186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10). AU - Lim,S C, AU - Tan,H H, AU - Goh,S K, AU - Subramaniam,T, AU - Sum,C F, AU - Tan,I K, AU - Lee,B L, AU - Ong,C N, PY - 2006/11/23/pubmed PY - 2007/5/22/medline PY - 2006/11/23/entrez SP - 1344 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 23 IS - 12 N2 - AIM: Individuals with diabetes and prediabetes are at risk of vascular injury. However, the exact mechanisms are unclear. The mitochondria mobile electron carrier coenzyme Q(10) (CoQ(10)) is a potent lipophilic antioxidant. We hypothesize that oxidative stress, detectable as changes in plasma CoQ(10) concentrations and composition, plays an important role in vascular disease in diabetes. METHODS: We measured plasma CoQ(10) concentrations (including reduced ubiquinol and oxidized ubiquinone subfractions) in 60 subjects with normal glucose tolerance [NGT; fasting plasma glucose (FPG) < 5.5 mmol/l], 63 with impaired fasting glucose (IFG; FPG 5.6-6.9 mmol/l) and 69 with Type 2 diabetes (DM; FPG > 6.9 mmol/l). RESULTS: In men and women, the total CoQ(10)/total cholesterol ratio was reduced in DM (mean +/-sd) [male (M) 0.09 +/- 0.04; female (F) 0.07 +/- 0.04] compared with NGT (0.29 +/- 0.08; 0.21 +/- 0.07) and IFG (0.27 +/- 0.07; 0.23 +/- 0.07) (DM vs. NGT and IFG P = 0.001). A stepwise reduction in the plasma ubiquinol fraction (ubiquinol/total CoQ10) was observed from NGT (M 0.93 +/- 0.06; F 0.95 +/- 0.06) compared with IFG (0.43 +/- 0.25; 0.41 +/- 0.15) and DM (0.24 +/- 0.11; F 0.29 +/- 0.16) (DM vs. IFG vs. NGT P = 0.001). In contrast, the plasma ubiquinone/ubiquinol ratio increased from NGT (M 0.08 +/- 0.07, F 0.06 +/- 0.08) to IFG (2.14 +/- 1.84, 1.75 +/- 1.04) to DM (4.77 +/- 4.88, 3.81 +/- 3.71) (DM vs. IFG vs. NGT P = 0.001). These differences remained after adjusting for age, body mass index and FPG. CONCLUSIONS: The change in CoQ(10) with increasing FPG concentration suggests an increase in oxidative burden, already evident in the prediabetic IFG individuals. This increase in oxidative stress might contribute to the increased risk of vascular disease. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17116186/Oxidative_burden_in_prediabetic_and_diabetic_individuals:_evidence_from_plasma_coenzyme_Q_10__ L2 - https://doi.org/10.1111/j.1464-5491.2006.01996.x DB - PRIME DP - Unbound Medicine ER -