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Macrolide and ketolide resistance with Streptococcus pneumoniae.
Med Clin North Am. 2006 Nov; 90(6):1109-24.MC

Abstract

Antimicrobial agents in the macrolide family have long been considered drugs of potential utility in the management of infections caused by Streptococcus pneumoniae. However, with the emergence of macrolide resistance, the clinical value of macrolides in pneumococcal infections is threatened. In part, as a consequence of the development of macrolide resistance, recently the first agent in the ketolide antimicrobial class, telithromycin, was developed and introduced into clinical practice. The ketolides are macrolide antimicrobials whose chemistry has been modified so as avoid the effects of the most common mechanisms of macrolide resistance with S pneumoniae. This discussion reviews the current state of resistance to macrolides and ketolides with S pneumoniae in North America.

Authors+Show Affiliations

Doern GV
Clinical Microbiology Laboratories, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. gary-doern@uiowa.edu

MeSH

Anti-Bacterial AgentsAzithromycinBacterial ProteinsClarithromycinDrug Resistance, BacterialHumansKetolidesMacrolidesMembrane ProteinsPneumococcal InfectionsStreptococcus pneumoniae

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17116439

Citation

Doern, Gary V.. "Macrolide and Ketolide Resistance With Streptococcus Pneumoniae." The Medical Clinics of North America, vol. 90, no. 6, 2006, pp. 1109-24.
Doern GV. Macrolide and ketolide resistance with Streptococcus pneumoniae. Med Clin North Am. 2006;90(6):1109-24.
Doern, G. V. (2006). Macrolide and ketolide resistance with Streptococcus pneumoniae. The Medical Clinics of North America, 90(6), 1109-24.
Doern GV. Macrolide and Ketolide Resistance With Streptococcus Pneumoniae. Med Clin North Am. 2006;90(6):1109-24. PubMed PMID: 17116439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrolide and ketolide resistance with Streptococcus pneumoniae. A1 - Doern,Gary V, PY - 2006/11/23/pubmed PY - 2007/1/16/medline PY - 2006/11/23/entrez SP - 1109 EP - 24 JF - The Medical clinics of North America JO - Med Clin North Am VL - 90 IS - 6 N2 - Antimicrobial agents in the macrolide family have long been considered drugs of potential utility in the management of infections caused by Streptococcus pneumoniae. However, with the emergence of macrolide resistance, the clinical value of macrolides in pneumococcal infections is threatened. In part, as a consequence of the development of macrolide resistance, recently the first agent in the ketolide antimicrobial class, telithromycin, was developed and introduced into clinical practice. The ketolides are macrolide antimicrobials whose chemistry has been modified so as avoid the effects of the most common mechanisms of macrolide resistance with S pneumoniae. This discussion reviews the current state of resistance to macrolides and ketolides with S pneumoniae in North America. SN - 0025-7125 UR - https://www.unboundmedicine.com/medline/citation/17116439/Macrolide_and_ketolide_resistance_with_Streptococcus_pneumoniae_ DB - PRIME DP - Unbound Medicine ER -