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Progress in the development of the DexAide right ventricular assist device.
ASAIO J. 2006 Nov-Dec; 52(6):630-3.AJ

Abstract

The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing. In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way.

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Authors+Show Affiliations

Fukamachi K
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ootaki Y
No affiliation info available
Horvath DJ
No affiliation info available
Massiello AL
No affiliation info available
Kamohara K
No affiliation info available
Akiyama M
No affiliation info available
Cingoz F
No affiliation info available
Ootaki C
No affiliation info available
Kopcak MW
No affiliation info available
Dessoffy R
No affiliation info available
Liu J
No affiliation info available
Chen JF
No affiliation info available
Zhou Q
No affiliation info available
Benefit S
No affiliation info available
Golding LA
No affiliation info available
Alfini S
No affiliation info available
Rowe DT
No affiliation info available

MeSH

AnimalsBiomedical EngineeringBlood PressureCattleHeart FailureHeart-Assist DevicesHumansProsthesis DesignPulsatile Flow

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17117051

Citation

Fukamachi, Kiyotaka, et al. "Progress in the Development of the DexAide Right Ventricular Assist Device." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 52, no. 6, 2006, pp. 630-3.
Fukamachi K, Ootaki Y, Horvath DJ, et al. Progress in the development of the DexAide right ventricular assist device. ASAIO J. 2006;52(6):630-3.
Fukamachi, K., Ootaki, Y., Horvath, D. J., Massiello, A. L., Kamohara, K., Akiyama, M., Cingoz, F., Ootaki, C., Kopcak, M. W., Dessoffy, R., Liu, J., Chen, J. F., Zhou, Q., Benefit, S., Golding, L. A., Alfini, S., & Rowe, D. T. (2006). Progress in the development of the DexAide right ventricular assist device. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 52(6), 630-3.
Fukamachi K, et al. Progress in the Development of the DexAide Right Ventricular Assist Device. ASAIO J. 2006 Nov-Dec;52(6):630-3. PubMed PMID: 17117051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progress in the development of the DexAide right ventricular assist device. AU - Fukamachi,Kiyotaka, AU - Ootaki,Yoshio, AU - Horvath,David J, AU - Massiello,Alex L, AU - Kamohara,Keiji, AU - Akiyama,Masatoshi, AU - Cingoz,Faruk, AU - Ootaki,Chiyo, AU - Kopcak,Michael W,Jr AU - Dessoffy,Raymond, AU - Liu,Jenny, AU - Chen,Ji-Feng, AU - Zhou,Qun, AU - Benefit,Stephen, AU - Golding,Leonard A R, AU - Alfini,Sue, AU - Rowe,David T, PY - 2006/11/23/pubmed PY - 2007/1/19/medline PY - 2006/11/23/entrez SP - 630 EP - 3 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 52 IS - 6 N2 - The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing. In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/17117051/Progress_in_the_development_of_the_DexAide_right_ventricular_assist_device_ L2 - https://doi.org/10.1097/01.mat.0000240700.03478.d0 DB - PRIME DP - Unbound Medicine ER -