Prime

Type your tag names separated by a space and hit enter

Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release.

Abstract

Novel composite poly(N-isopropylacrylamide) (PNIPAAm) hydrogels, containing poly(N-isopropylacrylamide)-block-poly(methyl methacrylate) (PNIPAAm-b-PMMA) micelles for sustained drug delivery were prepared and characterized. Various amounts of thermal sensitive PNIPAAm-b-PMMA micelles were incorporated physically into thermosensitive PNIPAAm bulk hydrogel to form composite PNIPAAm hydrogels. The resultant composite hydrogels were characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) for morphological and thermal properties, respectively. The temperature dependence of swelling ratio and response kinetics upon heating or cooling were also investigated to understand the smart properties, that is, temperature-sensitive properties of the composite PNIPAAm hydrogels. These composite PNIPAAm hydrogels exhibited a faster shrinking kinetics than the one of pure PNIPAAm hydrogels. In addition, prednisone acetate, used as model drug, was loaded into the micelles incorporated to the composite PNIPAAm hydrogels. The controlled release behavior of the novel composite PNIPAAm hydrogels at different temperatures (22 and 37 degrees C) was examined.

Links

  • Publisher Full Text
  • Authors

    , , , ,

    Source

    MeSH

    Acrylic Resins
    Biocompatible Materials
    Delayed-Action Preparations
    Drug Delivery Systems
    Hydrogels
    Materials Testing
    Micelles
    Microscopy, Electron, Scanning
    Prednisone
    Temperature

    Pub Type(s)

    In Vitro
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17117471

    Citation

    TY - JOUR T1 - Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release. AU - Xu,Xiao-Ding, AU - Wei,Hua, AU - Zhang,Xian-Zheng, AU - Cheng,Si-Xue, AU - Zhuo,Ren-Xi, PY - 2006/11/23/pubmed PY - 2007/7/12/medline PY - 2006/11/23/entrez SP - 418 EP - 26 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 81 IS - 2 N2 - Novel composite poly(N-isopropylacrylamide) (PNIPAAm) hydrogels, containing poly(N-isopropylacrylamide)-block-poly(methyl methacrylate) (PNIPAAm-b-PMMA) micelles for sustained drug delivery were prepared and characterized. Various amounts of thermal sensitive PNIPAAm-b-PMMA micelles were incorporated physically into thermosensitive PNIPAAm bulk hydrogel to form composite PNIPAAm hydrogels. The resultant composite hydrogels were characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) for morphological and thermal properties, respectively. The temperature dependence of swelling ratio and response kinetics upon heating or cooling were also investigated to understand the smart properties, that is, temperature-sensitive properties of the composite PNIPAAm hydrogels. These composite PNIPAAm hydrogels exhibited a faster shrinking kinetics than the one of pure PNIPAAm hydrogels. In addition, prednisone acetate, used as model drug, was loaded into the micelles incorporated to the composite PNIPAAm hydrogels. The controlled release behavior of the novel composite PNIPAAm hydrogels at different temperatures (22 and 37 degrees C) was examined. SN - 1549-3296 UR - https://www.unboundmedicine.com/medline/citation/17117471/Fabrication_and_characterization_of_a_novel_composite_PNIPAAm_hydrogel_for_controlled_drug_release_ L2 - http://dx.doi.org/10.1002/jbm.a.31063 ER -