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Current concepts and treatment options in eosinophilic esophagitis.
Curr Opin Investig Drugs 2006; 7(11):992-6CO

Abstract

Eosinophilic esophagitis (EE) is an inflammatory disorder of the esophagus that affects both children and adults, and is different from gastro-esophageal reflux disease. The immunopathogenesis of EE involves an allergic response to environmental and food allergens, and the proinflammatory cytokines IL-5 and IL-13. EE may be associated with atopic disorders and peripheral eosinophilia, and may be familial in distribution. The most common presentation is dysphagia and food impaction in adults, with additional manifestations of epigastric pain, emesis, weight loss and failure to thrive in children. Typical endoscopic findings include ringed esophagus, linear furrows, strictures and narrow esophagus. Diagnosis is confirmed by the presence of 20 or more eosinophils per high power field in the esophagus. The available treatment options include elemental diet, avoidance of specific food allergens, topical and systemic corticosteroids, and humanized monoclonal antibodies against IL-5. This review summarizes the etiopathogenesis, clinical, endoscopic and histopathological findings in EE, and describes current available treatment options.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17117587

Citation

Pasha, Shabana F., et al. "Current Concepts and Treatment Options in Eosinophilic Esophagitis." Current Opinion in Investigational Drugs (London, England : 2000), vol. 7, no. 11, 2006, pp. 992-6.
Pasha SF, Sharma VK, Crowell MD. Current concepts and treatment options in eosinophilic esophagitis. Curr Opin Investig Drugs. 2006;7(11):992-6.
Pasha, S. F., Sharma, V. K., & Crowell, M. D. (2006). Current concepts and treatment options in eosinophilic esophagitis. Current Opinion in Investigational Drugs (London, England : 2000), 7(11), pp. 992-6.
Pasha SF, Sharma VK, Crowell MD. Current Concepts and Treatment Options in Eosinophilic Esophagitis. Curr Opin Investig Drugs. 2006;7(11):992-6. PubMed PMID: 17117587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts and treatment options in eosinophilic esophagitis. AU - Pasha,Shabana F, AU - Sharma,Virender K, AU - Crowell,Michael D, PY - 2006/11/23/pubmed PY - 2007/3/10/medline PY - 2006/11/23/entrez SP - 992 EP - 6 JF - Current opinion in investigational drugs (London, England : 2000) JO - Curr Opin Investig Drugs VL - 7 IS - 11 N2 - Eosinophilic esophagitis (EE) is an inflammatory disorder of the esophagus that affects both children and adults, and is different from gastro-esophageal reflux disease. The immunopathogenesis of EE involves an allergic response to environmental and food allergens, and the proinflammatory cytokines IL-5 and IL-13. EE may be associated with atopic disorders and peripheral eosinophilia, and may be familial in distribution. The most common presentation is dysphagia and food impaction in adults, with additional manifestations of epigastric pain, emesis, weight loss and failure to thrive in children. Typical endoscopic findings include ringed esophagus, linear furrows, strictures and narrow esophagus. Diagnosis is confirmed by the presence of 20 or more eosinophils per high power field in the esophagus. The available treatment options include elemental diet, avoidance of specific food allergens, topical and systemic corticosteroids, and humanized monoclonal antibodies against IL-5. This review summarizes the etiopathogenesis, clinical, endoscopic and histopathological findings in EE, and describes current available treatment options. SN - 1472-4472 UR - https://www.unboundmedicine.com/medline/citation/17117587/Current_concepts_and_treatment_options_in_eosinophilic_esophagitis_ L2 - https://medlineplus.gov/eosinophilicdisorders.html DB - PRIME DP - Unbound Medicine ER -