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Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects.
J Ethnopharmacol. 2007 Apr 04; 110(3):504-15.JE

Abstract

Extracts obtained from the dried aerial parts of Clematis species are used as folk remedy worldwide for the treatment of various inflammatory ailments such as rheumatism and to reduce fever. In order to test the effectiveness of extracts, fractions and subfractions from dried Clematis vitalba L. (Ranunculaceae) aerial parts were studied on mice. Extracts are shown to have a potent effect on carrageenan-induced hind paw edema and acetic acid-induced increased vascular permeability models. Through bioassay-guided fractionation procedures a new C-glycosylflavon, 4'-O-coumaroyl-isovitexine (vitalboside) was isolated as the main active ingredient of the aerial parts. Vitalboside showed a potent and dose-dependent (in 75 and 150 mg/kg does, per os) in vivo anti-inflammatory activity against acute (carrageenan-, serotonin- and PGE(2)-induced hind paw edema model, castor oil-induced diarrhea), subacute (subcutaneous air-pouch) and chronic (Freund's complete adjuvant-induced arthritis) models of inflammation. The same compound was also isolated as the main antinociceptive principle which was assessed by using the models based on the inhibition of p-benzoquinone-induced writhings, as well as antipyretic activity against Freund's complete adjuvant-induced increased body temperature. Acute and subchronic toxicity studies were also performed.

Authors+Show Affiliations

Yeditepe University, Kayişdaği 34755, Istanbul. yesilada@yeditepe.edu.trNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17118593

Citation

Yesilada, Erdem, and Esra Küpeli. "Clematis Vitalba L. Aerial Part Exhibits Potent Anti-inflammatory, Antinociceptive and Antipyretic Effects." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 504-15.
Yesilada E, Küpeli E. Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. J Ethnopharmacol. 2007;110(3):504-15.
Yesilada, E., & Küpeli, E. (2007). Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. Journal of Ethnopharmacology, 110(3), 504-15.
Yesilada E, Küpeli E. Clematis Vitalba L. Aerial Part Exhibits Potent Anti-inflammatory, Antinociceptive and Antipyretic Effects. J Ethnopharmacol. 2007 Apr 4;110(3):504-15. PubMed PMID: 17118593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. AU - Yesilada,Erdem, AU - Küpeli,Esra, Y1 - 2006/10/20/ PY - 2006/07/25/received PY - 2006/10/02/revised PY - 2006/10/12/accepted PY - 2006/11/23/pubmed PY - 2007/6/15/medline PY - 2006/11/23/entrez SP - 504 EP - 15 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - Extracts obtained from the dried aerial parts of Clematis species are used as folk remedy worldwide for the treatment of various inflammatory ailments such as rheumatism and to reduce fever. In order to test the effectiveness of extracts, fractions and subfractions from dried Clematis vitalba L. (Ranunculaceae) aerial parts were studied on mice. Extracts are shown to have a potent effect on carrageenan-induced hind paw edema and acetic acid-induced increased vascular permeability models. Through bioassay-guided fractionation procedures a new C-glycosylflavon, 4'-O-coumaroyl-isovitexine (vitalboside) was isolated as the main active ingredient of the aerial parts. Vitalboside showed a potent and dose-dependent (in 75 and 150 mg/kg does, per os) in vivo anti-inflammatory activity against acute (carrageenan-, serotonin- and PGE(2)-induced hind paw edema model, castor oil-induced diarrhea), subacute (subcutaneous air-pouch) and chronic (Freund's complete adjuvant-induced arthritis) models of inflammation. The same compound was also isolated as the main antinociceptive principle which was assessed by using the models based on the inhibition of p-benzoquinone-induced writhings, as well as antipyretic activity against Freund's complete adjuvant-induced increased body temperature. Acute and subchronic toxicity studies were also performed. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17118593/Clematis_vitalba_L__aerial_part_exhibits_potent_anti_inflammatory_antinociceptive_and_antipyretic_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00531-9 DB - PRIME DP - Unbound Medicine ER -