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Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 01; 848(2):355-62.JC

Abstract

The root of Scutellaria baicalensis, called Huangqin in Chinese, is one of the most commonly used traditional Chinese medicines for the treatment of hepatitis, tumors, diarrhea, and inflammatory diseases. The major chemical constituents of Huangqin are flavonoids. In the present paper, HPLC-DAD-ESI-MS(n) was used to analyze flavonoids in the roots of S. baicalensis. A total of 26 flavonoids were identified or tentatively characterized, including 5 C-glycosides, 12 O-glycosides, and 9 free aglycones. Two C-glycosides, apigenin-6-C-glucyl-8-C-arabinoside and chrysin-6,8-di-C-glucoside, together with some O-glycosides, are reported from S. baicalensis for the first time. This method is simple, reliable and sensitive, and could be used for the quality control of Huangqin and its related preparations.

Authors+Show Affiliations

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17118721

Citation

Han, Jian, et al. "Characterization of Flavonoids in the Traditional Chinese Herbal medicine-Huangqin By Liquid Chromatography Coupled With Electrospray Ionization Mass Spectrometry." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 848, no. 2, 2007, pp. 355-62.
Han J, Ye M, Xu M, et al. Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;848(2):355-62.
Han, J., Ye, M., Xu, M., Sun, J., Wang, B., & Guo, D. (2007). Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 848(2), 355-62.
Han J, et al. Characterization of Flavonoids in the Traditional Chinese Herbal medicine-Huangqin By Liquid Chromatography Coupled With Electrospray Ionization Mass Spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 1;848(2):355-62. PubMed PMID: 17118721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. AU - Han,Jian, AU - Ye,Min, AU - Xu,Man, AU - Sun,Jianghao, AU - Wang,Baorong, AU - Guo,Dean, Y1 - 2006/11/21/ PY - 2006/08/02/received PY - 2006/10/23/revised PY - 2006/10/29/accepted PY - 2006/11/23/pubmed PY - 2007/6/15/medline PY - 2006/11/23/entrez SP - 355 EP - 62 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 848 IS - 2 N2 - The root of Scutellaria baicalensis, called Huangqin in Chinese, is one of the most commonly used traditional Chinese medicines for the treatment of hepatitis, tumors, diarrhea, and inflammatory diseases. The major chemical constituents of Huangqin are flavonoids. In the present paper, HPLC-DAD-ESI-MS(n) was used to analyze flavonoids in the roots of S. baicalensis. A total of 26 flavonoids were identified or tentatively characterized, including 5 C-glycosides, 12 O-glycosides, and 9 free aglycones. Two C-glycosides, apigenin-6-C-glucyl-8-C-arabinoside and chrysin-6,8-di-C-glucoside, together with some O-glycosides, are reported from S. baicalensis for the first time. This method is simple, reliable and sensitive, and could be used for the quality control of Huangqin and its related preparations. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/17118721/Characterization_of_flavonoids_in_the_traditional_Chinese_herbal_medicine_Huangqin_by_liquid_chromatography_coupled_with_electrospray_ionization_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(06)00877-4 DB - PRIME DP - Unbound Medicine ER -