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Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa women's health study.

Abstract

BACKGROUND

Previous studies have suggested that use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk of lung cancer, but the data are inconsistent and are limited particularly with respect to the effects of aspirin, separate from other NSAIDs.

METHODS

The Iowa Women's Health Study is a prospective cohort of 41,836 Iowa women ages 55 to 69 years old at baseline in 1986. NSAID use was assessed in 1992. Over 10 years of follow-up, 403 incident cases of lung cancer were identified. The association of incident lung cancer with current use of aspirin or non-aspirin NSAIDs was analyzed after adjustment for lung cancer risk factors. Hazard ratios (HR) were estimated using multivariate COX proportional hazards regression.

RESULTS

There were 27,162 women in the analytic cohort. After controlling for age, education, alcohol intake, pack-years, smoking status, body mass index, and total fruit intake, the RR of women taking six or more aspirin weekly was 1.21 (95% confidence interval, 0.92-1.59). The HR was 1.23 for women taking six or more non-aspirin NSAIDs weekly (95% confidence interval, 0.92-1.65). There was no statistically significant trend by frequency of use for either aspirin (P(trend) = 0.22) or non-aspirin NSAIDs (P(trend) = 0.53). Analyses by histologic type and smoking status yielded similar null results. Information on dosage and duration of use were not available for this analysis.

CONCLUSION

These findings do not suggest that aspirin or other NSAIDs reduce risk of lung cancer in this cohort of postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015, USA.

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    Source

    MeSH

    Aged
    Anti-Inflammatory Agents, Non-Steroidal
    Aspirin
    Body Mass Index
    Cohort Studies
    Female
    Follow-Up Studies
    Humans
    Incidence
    Iowa
    Lung Neoplasms
    Middle Aged
    Multivariate Analysis
    Postmenopause
    Proportional Hazards Models
    Smoking
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17119050

    Citation

    Hayes, Jennifer H., et al. "Association Between Nonsteroidal Anti-inflammatory Drug Use and the Incidence of Lung Cancer in the Iowa Women's Health Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 11, 2006, pp. 2226-31.
    Hayes JH, Anderson KE, Folsom AR. Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa women's health study. Cancer Epidemiol Biomarkers Prev. 2006;15(11):2226-31.
    Hayes, J. H., Anderson, K. E., & Folsom, A. R. (2006). Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa women's health study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(11), pp. 2226-31.
    Hayes JH, Anderson KE, Folsom AR. Association Between Nonsteroidal Anti-inflammatory Drug Use and the Incidence of Lung Cancer in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2006;15(11):2226-31. PubMed PMID: 17119050.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa women's health study. AU - Hayes,Jennifer H, AU - Anderson,Kristin E, AU - Folsom,Aaron R, PY - 2006/11/23/pubmed PY - 2007/6/15/medline PY - 2006/11/23/entrez SP - 2226 EP - 31 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 11 N2 - BACKGROUND: Previous studies have suggested that use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk of lung cancer, but the data are inconsistent and are limited particularly with respect to the effects of aspirin, separate from other NSAIDs. METHODS: The Iowa Women's Health Study is a prospective cohort of 41,836 Iowa women ages 55 to 69 years old at baseline in 1986. NSAID use was assessed in 1992. Over 10 years of follow-up, 403 incident cases of lung cancer were identified. The association of incident lung cancer with current use of aspirin or non-aspirin NSAIDs was analyzed after adjustment for lung cancer risk factors. Hazard ratios (HR) were estimated using multivariate COX proportional hazards regression. RESULTS: There were 27,162 women in the analytic cohort. After controlling for age, education, alcohol intake, pack-years, smoking status, body mass index, and total fruit intake, the RR of women taking six or more aspirin weekly was 1.21 (95% confidence interval, 0.92-1.59). The HR was 1.23 for women taking six or more non-aspirin NSAIDs weekly (95% confidence interval, 0.92-1.65). There was no statistically significant trend by frequency of use for either aspirin (P(trend) = 0.22) or non-aspirin NSAIDs (P(trend) = 0.53). Analyses by histologic type and smoking status yielded similar null results. Information on dosage and duration of use were not available for this analysis. CONCLUSION: These findings do not suggest that aspirin or other NSAIDs reduce risk of lung cancer in this cohort of postmenopausal women. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17119050/Association_between_nonsteroidal_anti_inflammatory_drug_use_and_the_incidence_of_lung_cancer_in_the_Iowa_women's_health_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17119050 DB - PRIME DP - Unbound Medicine ER -