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Inhibition of histamine release from rat peritoneal mast cells by MY-1250, an active metabolite of Repirinast (MY-5116).
Int Arch Allergy Appl Immunol. 1990; 93(2-3):237-41.IA

Abstract

MY-1250, an active metabolite of Repirinast (MY-5116), strongly and dose-dependently inhibited the in vitro histamine release from rat peritoneal mast cells induced by antigen. The IC50 value of MY-1250 for histamine release was in the order of 0.3 microM. Moreover MY-1250 strongly inhibited calcium ion mobilization from the intracellular Ca2+ store. In the presence of 3.6 x 10(-5) M of MY-1250, the initial rise in [Ca2+]i reached a maximum of only 13 nM, and the inhibitory effect was 81% for the initial rise. The IC50 value for this event was 0.25 microM. The inhibitory effect of MY-1250 on the initial rise in [Ca2+]i was closely correlated with that on histamine release.

Authors+Show Affiliations

Department of Pharmacology, Tokushima Bunri University, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1712003

Citation

Takei, M, et al. "Inhibition of Histamine Release From Rat Peritoneal Mast Cells By MY-1250, an Active Metabolite of Repirinast (MY-5116)." International Archives of Allergy and Applied Immunology, vol. 93, no. 2-3, 1990, pp. 237-41.
Takei M, Endo K, Takahashi K. Inhibition of histamine release from rat peritoneal mast cells by MY-1250, an active metabolite of Repirinast (MY-5116). Int Arch Allergy Appl Immunol. 1990;93(2-3):237-41.
Takei, M., Endo, K., & Takahashi, K. (1990). Inhibition of histamine release from rat peritoneal mast cells by MY-1250, an active metabolite of Repirinast (MY-5116). International Archives of Allergy and Applied Immunology, 93(2-3), 237-41.
Takei M, Endo K, Takahashi K. Inhibition of Histamine Release From Rat Peritoneal Mast Cells By MY-1250, an Active Metabolite of Repirinast (MY-5116). Int Arch Allergy Appl Immunol. 1990;93(2-3):237-41. PubMed PMID: 1712003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of histamine release from rat peritoneal mast cells by MY-1250, an active metabolite of Repirinast (MY-5116). AU - Takei,M, AU - Endo,K, AU - Takahashi,K, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 237 EP - 41 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 93 IS - 2-3 N2 - MY-1250, an active metabolite of Repirinast (MY-5116), strongly and dose-dependently inhibited the in vitro histamine release from rat peritoneal mast cells induced by antigen. The IC50 value of MY-1250 for histamine release was in the order of 0.3 microM. Moreover MY-1250 strongly inhibited calcium ion mobilization from the intracellular Ca2+ store. In the presence of 3.6 x 10(-5) M of MY-1250, the initial rise in [Ca2+]i reached a maximum of only 13 nM, and the inhibitory effect was 81% for the initial rise. The IC50 value for this event was 0.25 microM. The inhibitory effect of MY-1250 on the initial rise in [Ca2+]i was closely correlated with that on histamine release. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/1712003/Inhibition_of_histamine_release_from_rat_peritoneal_mast_cells_by_MY_1250_an_active_metabolite_of_Repirinast__MY_5116__ DB - PRIME DP - Unbound Medicine ER -