Tags

Type your tag names separated by a space and hit enter

Smoking and inflammatory bowel disease: a meta-analysis.

Abstract

OBJECTIVE

To assess whether there is a true effect of smoking on the 2 most prevalent forms of inflammatory bowel disease (IBD): Crohn disease (CD) and ulcerative colitis (UC).

METHODS

For this meta-analysis, we searched multiple health care databases, including MEDLINE and EMBASE (January 1980 to January 2006), to examine the relationship between smoking and IBD. Keywords searched included smoking, Inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Data were abstracted using predefined inclusion and exclusion criteria. An odds ratio (OR) was recalculated for each study using the random-effects model, and a combined OR was calculated.

RESULTS

A total of 245 articles were obtained through an electronic search of health care databases. Thirteen studies examined the relationship between UC and smoking, whereas 9 examined the relationship between CD and smoking. We found evidence of an association between current smoking and CD (OR, 1.76; 95% confidence interval [CI], 1.40-2.22) and former smoking and UC (OR, 1.79; 95% CI, 1.37-2.34). Current smoking had a protective effect on the development of UC when compared with controls (OR, 0.58; 95% CI, 0.45-0.75).

CONCLUSION

This is the first meta-analysis, to our knowledge, to evaluate the relationship between smoking and IBD using accepted quality standards for meta-analysis reporting. Our meta-analyses confirm that smoking is an important environmental factor in IBD with differing effects in UC and CD. By using predefined inclusion criteria and testing for homogeneity, the current analysis provides an estimate of the effect of smoking on both these forms of IBD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, Section of Colorectal Surgery, Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, KY 40292, USA.

    , , ,

    Source

    Mayo Clinic proceedings 81:11 2006 Nov pg 1462-71

    MeSH

    Humans
    Inflammatory Bowel Diseases
    Odds Ratio
    Prevalence
    Risk Factors
    Smoking
    United States

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17120402

    Citation

    Mahid, Suhal S., et al. "Smoking and Inflammatory Bowel Disease: a Meta-analysis." Mayo Clinic Proceedings, vol. 81, no. 11, 2006, pp. 1462-71.
    Mahid SS, Minor KS, Soto RE, et al. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clin Proc. 2006;81(11):1462-71.
    Mahid, S. S., Minor, K. S., Soto, R. E., Hornung, C. A., & Galandiuk, S. (2006). Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clinic Proceedings, 81(11), pp. 1462-71.
    Mahid SS, et al. Smoking and Inflammatory Bowel Disease: a Meta-analysis. Mayo Clin Proc. 2006;81(11):1462-71. PubMed PMID: 17120402.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Smoking and inflammatory bowel disease: a meta-analysis. AU - Mahid,Suhal S, AU - Minor,Kyle S, AU - Soto,Roberto E, AU - Hornung,Carlton A, AU - Galandiuk,Susan, PY - 2006/11/24/pubmed PY - 2006/12/9/medline PY - 2006/11/24/entrez SP - 1462 EP - 71 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 81 IS - 11 N2 - OBJECTIVE: To assess whether there is a true effect of smoking on the 2 most prevalent forms of inflammatory bowel disease (IBD): Crohn disease (CD) and ulcerative colitis (UC). METHODS: For this meta-analysis, we searched multiple health care databases, including MEDLINE and EMBASE (January 1980 to January 2006), to examine the relationship between smoking and IBD. Keywords searched included smoking, Inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Data were abstracted using predefined inclusion and exclusion criteria. An odds ratio (OR) was recalculated for each study using the random-effects model, and a combined OR was calculated. RESULTS: A total of 245 articles were obtained through an electronic search of health care databases. Thirteen studies examined the relationship between UC and smoking, whereas 9 examined the relationship between CD and smoking. We found evidence of an association between current smoking and CD (OR, 1.76; 95% confidence interval [CI], 1.40-2.22) and former smoking and UC (OR, 1.79; 95% CI, 1.37-2.34). Current smoking had a protective effect on the development of UC when compared with controls (OR, 0.58; 95% CI, 0.45-0.75). CONCLUSION: This is the first meta-analysis, to our knowledge, to evaluate the relationship between smoking and IBD using accepted quality standards for meta-analysis reporting. Our meta-analyses confirm that smoking is an important environmental factor in IBD with differing effects in UC and CD. By using predefined inclusion criteria and testing for homogeneity, the current analysis provides an estimate of the effect of smoking on both these forms of IBD. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/17120402/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)61253-6 DB - PRIME DP - Unbound Medicine ER -