Tags

Type your tag names separated by a space and hit enter

Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma.
Mol Hum Reprod. 2007 Feb; 13(2):117-22.MH

Abstract

Endometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor alpha (ERalpha)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis (n = 112), (ii) leiomyoma (n = 106) and (iii) normal controls (n = 110). Genomic DNA was obtained from peripheral leukocytes. ERalpha-351 A/G XbaI and -397 T/C PvuII polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ERalpha-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ERalpha mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ERalpha-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ERalpha-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ERalpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung and Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17121748

Citation

Hsieh, Y-Y, et al. "Estrogen Receptor Alpha-351 XbaI*G and -397 PvuII*C-related Genotypes and Alleles Are Associated With Higher Susceptibilities of Endometriosis and Leiomyoma." Molecular Human Reproduction, vol. 13, no. 2, 2007, pp. 117-22.
Hsieh YY, Wang YK, Chang CC, et al. Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. Mol Hum Reprod. 2007;13(2):117-22.
Hsieh, Y. Y., Wang, Y. K., Chang, C. C., & Lin, C. S. (2007). Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. Molecular Human Reproduction, 13(2), 117-22.
Hsieh YY, et al. Estrogen Receptor Alpha-351 XbaI*G and -397 PvuII*C-related Genotypes and Alleles Are Associated With Higher Susceptibilities of Endometriosis and Leiomyoma. Mol Hum Reprod. 2007;13(2):117-22. PubMed PMID: 17121748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. AU - Hsieh,Y-Y, AU - Wang,Y-K, AU - Chang,C-C, AU - Lin,C-S, Y1 - 2006/11/22/ PY - 2006/11/24/pubmed PY - 2007/5/30/medline PY - 2006/11/24/entrez SP - 117 EP - 22 JF - Molecular human reproduction JO - Mol Hum Reprod VL - 13 IS - 2 N2 - Endometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor alpha (ERalpha)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis (n = 112), (ii) leiomyoma (n = 106) and (iii) normal controls (n = 110). Genomic DNA was obtained from peripheral leukocytes. ERalpha-351 A/G XbaI and -397 T/C PvuII polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ERalpha-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ERalpha mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ERalpha-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ERalpha-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ERalpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses. SN - 1360-9947 UR - https://www.unboundmedicine.com/medline/citation/17121748/Estrogen_receptor_alpha_351_XbaI_G_and__397_PvuII_C_related_genotypes_and_alleles_are_associated_with_higher_susceptibilities_of_endometriosis_and_leiomyoma_ L2 - https://academic.oup.com/molehr/article-lookup/doi/10.1093/molehr/gal099 DB - PRIME DP - Unbound Medicine ER -