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The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study.
Anesth Analg. 2006 Dec; 103(6):1448-52.A&A

Abstract

BACKGROUND

The effect of melatonin on the intraoperative requirements for i.v.anesthetics has not been documented. We studied the effect of melatonin premedication on the propofol and thiopental dose-response curves for abolition of responses to verbal commands and eyelash stimulation.

METHODS

This prospective, randomized, double-blind study included 200 adults with ASA physical status I. Patients received either 0.2 mg/kg melatonin or a placebo orally for premedication (n = 100 per group). Approximately 50 min later, subgroups of 10 melatonin and 10 placebo patients were administered various doses of propofol (0.5, 1.0, 1.5, 2.0, or 2.4 mg/kg) or thiopental (2.0, 3.0, 4.0, 5.0, or 6.0 mg/kg) for anesthetic induction. The ability of each patient to respond to the command, "open your eyes," and the disappearance of the eyelash reflex were assessed 60 s after the end of the injection of propofol or thiopental. Dose-response curves were determined by probit analysis.

RESULTS

Melatonin premedication decreased thiopental ED50 values for loss of response to verbal command and eyelash reflex from 3.4 mg/kg (95% confidence interval, 3.2-3.5 mg/kg) and 3.7 mg/kg (3.5-3.9 mg/kg) to 2.7 mg/kg (2.6-2.9 mg/kg) and 2.6 mg/kg (2.5-2.7 mg/kg), respectively (P < 0.05). Corresponding propofol ED50 values decreased from 1.5 mg/kg (1.4-1.6 mg/kg) and 1.6 mg/kg (1.5-1.7 mg/kg) to 0.9 mg/kg (0.8-0.96 mg/kg) and 0.9 mg/kg (0.8-0.95 mg/kg), respectively (P < 0.05).

CONCLUSIONS

Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, University of Texas M.D. Anderson Cancer Center, Unit 409, 1400 Holcombe Boulevard, Houston, TX 77030, USA. naguib@mdanderson.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17122221

Citation

Naguib, Mohamed, et al. "The Effects of Melatonin Premedication On Propofol and Thiopental Induction Dose-response Curves: a Prospective, Randomized, Double-blind Study." Anesthesia and Analgesia, vol. 103, no. 6, 2006, pp. 1448-52.
Naguib M, Samarkandi AH, Moniem MA, et al. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesth Analg. 2006;103(6):1448-52.
Naguib, M., Samarkandi, A. H., Moniem, M. A., Mansour, E. e. l. -. D., Alshaer, A. A., Al-Ayyaf, H. A., Fadin, A., & Alharby, S. W. (2006). The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesthesia and Analgesia, 103(6), 1448-52.
Naguib M, et al. The Effects of Melatonin Premedication On Propofol and Thiopental Induction Dose-response Curves: a Prospective, Randomized, Double-blind Study. Anesth Analg. 2006;103(6):1448-52. PubMed PMID: 17122221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. AU - Naguib,Mohamed, AU - Samarkandi,Abdulhamid H, AU - Moniem,Mohamed A, AU - Mansour,Emad El-Din, AU - Alshaer,Ahmad A, AU - Al-Ayyaf,Hasan A, AU - Fadin,Awatif, AU - Alharby,Saleh W, PY - 2006/11/24/pubmed PY - 2006/12/9/medline PY - 2006/11/24/entrez SP - 1448 EP - 52 JF - Anesthesia and analgesia JO - Anesth Analg VL - 103 IS - 6 N2 - BACKGROUND: The effect of melatonin on the intraoperative requirements for i.v.anesthetics has not been documented. We studied the effect of melatonin premedication on the propofol and thiopental dose-response curves for abolition of responses to verbal commands and eyelash stimulation. METHODS: This prospective, randomized, double-blind study included 200 adults with ASA physical status I. Patients received either 0.2 mg/kg melatonin or a placebo orally for premedication (n = 100 per group). Approximately 50 min later, subgroups of 10 melatonin and 10 placebo patients were administered various doses of propofol (0.5, 1.0, 1.5, 2.0, or 2.4 mg/kg) or thiopental (2.0, 3.0, 4.0, 5.0, or 6.0 mg/kg) for anesthetic induction. The ability of each patient to respond to the command, "open your eyes," and the disappearance of the eyelash reflex were assessed 60 s after the end of the injection of propofol or thiopental. Dose-response curves were determined by probit analysis. RESULTS: Melatonin premedication decreased thiopental ED50 values for loss of response to verbal command and eyelash reflex from 3.4 mg/kg (95% confidence interval, 3.2-3.5 mg/kg) and 3.7 mg/kg (3.5-3.9 mg/kg) to 2.7 mg/kg (2.6-2.9 mg/kg) and 2.6 mg/kg (2.5-2.7 mg/kg), respectively (P < 0.05). Corresponding propofol ED50 values decreased from 1.5 mg/kg (1.4-1.6 mg/kg) and 1.6 mg/kg (1.5-1.7 mg/kg) to 0.9 mg/kg (0.8-0.96 mg/kg) and 0.9 mg/kg (0.8-0.95 mg/kg), respectively (P < 0.05). CONCLUSIONS: Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/17122221/The_effects_of_melatonin_premedication_on_propofol_and_thiopental_induction_dose_response_curves:_a_prospective_randomized_double_blind_study_ L2 - https://doi.org/10.1213/01.ane.0000244534.24216.3a DB - PRIME DP - Unbound Medicine ER -