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The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study.
Anesth Analg. 2006 Dec; 103(6):1459-63.A&A

Abstract

Dopamine release in the nucleus accumbens (NAC) plays a crucial role in the action of various psychotropic and addictive drugs, such as antagonists of the N-methyl-D-aspartate subtype of the glutamate. Although both nitrous oxide and xenon are N-methyl-D-aspartate receptor antagonists, they differ in their potential for producing neuropsychological toxicity; therefore, we decided to examine their effects on both spontaneous and ketamine-induced extracellular dopamine levels in the NAC. A microdialysis probe was implanted into the NAC in each of 35 rats, which were randomly assigned to one of six groups: exposure to 40% O2, exposure to 60% nitrous oxide (0.27 MAC), exposure to 43% xenon (0.27 MAC) for 60 min, and three groups exposed to either 40% O2, 60% nitrous oxide, or 43% xenon for 70 min and 80 mg/kg ketamine was given i.p. 10 min after the initiation of gas exposure. Perfusate samples were collected every 20 min, and the dopamine levels were measured using a high-performance liquid chromatography system. Nitrous oxide, but not xenon, significantly increased the dopamine level. Ketamine significantly increased the dopamine level, and this was significantly inhibited by xenon, but not by nitrous oxide. These data suggest that the difference in neuropsychological activity between nitrous oxide and xenon is partly due to their differential effects on the mesolimbic dopamine system.

Authors+Show Affiliations

Department of Anesthesiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-shi, Osaka 570-8507, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17122223

Citation

Sakamoto, Sachiyo, et al. "The Differential Effects of Nitrous Oxide and Xenon On Extracellular Dopamine Levels in the Rat Nucleus Accumbens: a Microdialysis Study." Anesthesia and Analgesia, vol. 103, no. 6, 2006, pp. 1459-63.
Sakamoto S, Nakao S, Masuzawa M, et al. The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesth Analg. 2006;103(6):1459-63.
Sakamoto, S., Nakao, S., Masuzawa, M., Inada, T., Maze, M., Franks, N. P., & Shingu, K. (2006). The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesthesia and Analgesia, 103(6), 1459-63.
Sakamoto S, et al. The Differential Effects of Nitrous Oxide and Xenon On Extracellular Dopamine Levels in the Rat Nucleus Accumbens: a Microdialysis Study. Anesth Analg. 2006;103(6):1459-63. PubMed PMID: 17122223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. AU - Sakamoto,Sachiyo, AU - Nakao,Shinichi, AU - Masuzawa,Munehiro, AU - Inada,Takefumi, AU - Maze,Mervyn, AU - Franks,Nicholas P, AU - Shingu,Koh, PY - 2006/11/24/pubmed PY - 2006/12/9/medline PY - 2006/11/24/entrez SP - 1459 EP - 63 JF - Anesthesia and analgesia JO - Anesth Analg VL - 103 IS - 6 N2 - Dopamine release in the nucleus accumbens (NAC) plays a crucial role in the action of various psychotropic and addictive drugs, such as antagonists of the N-methyl-D-aspartate subtype of the glutamate. Although both nitrous oxide and xenon are N-methyl-D-aspartate receptor antagonists, they differ in their potential for producing neuropsychological toxicity; therefore, we decided to examine their effects on both spontaneous and ketamine-induced extracellular dopamine levels in the NAC. A microdialysis probe was implanted into the NAC in each of 35 rats, which were randomly assigned to one of six groups: exposure to 40% O2, exposure to 60% nitrous oxide (0.27 MAC), exposure to 43% xenon (0.27 MAC) for 60 min, and three groups exposed to either 40% O2, 60% nitrous oxide, or 43% xenon for 70 min and 80 mg/kg ketamine was given i.p. 10 min after the initiation of gas exposure. Perfusate samples were collected every 20 min, and the dopamine levels were measured using a high-performance liquid chromatography system. Nitrous oxide, but not xenon, significantly increased the dopamine level. Ketamine significantly increased the dopamine level, and this was significantly inhibited by xenon, but not by nitrous oxide. These data suggest that the difference in neuropsychological activity between nitrous oxide and xenon is partly due to their differential effects on the mesolimbic dopamine system. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/17122223/The_differential_effects_of_nitrous_oxide_and_xenon_on_extracellular_dopamine_levels_in_the_rat_nucleus_accumbens:_a_microdialysis_study_ L2 - https://doi.org/10.1213/01.ane.0000247792.03959.f1 DB - PRIME DP - Unbound Medicine ER -