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Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham.
J Ethnopharmacol. 2007 Apr 04; 110(3):444-50.JE

Abstract

Infusions of Verbascumlasianthum flowers have been used for hemorrhoids in Turkish folk medicine. In order to evaluate the scientific basis for this practice, in vivo anti-inflammatory and antinociceptive activities of Verbascum lasianthum Boiss. ex Bentham flowers were investigated. A methanolic extract of the flowers was shown to possess significant inhibitory activity in the carrageenan-induced hind paw edema model and in p-benzoquinone-induced writhings in mice. Through bioassay-guided fractionation and isolation procedures eight compounds, 6-O-(4'''-O-trans-p-coumaroyl)-alpha-L-rhamnopyranosylaucubin (1), 6-O-(4'''-O-trans-p-methoxycinnamoyl)-alpha-L-rhamnopyranosylaucubin (2), sinuatol (3), aucubin (4), geniposidic acid (5), catalpol (6), ajugol (7) and ilwensisaponin A (8) were isolated and their structures were elucidated by spectral techniques. An iridoid glucoside, aucubin (4) and a triterpenoid saponin, ilwensisaponin A (8) were found to possess significant antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity or gastric damage. Results of the present study support the continued and expanded utilization of plants employed in Turkish folk medicine.

Authors+Show Affiliations

Gazi University, Etiler, 06330 Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17123759

Citation

Kupeli, Esra, et al. "Bioassay-guided Isolation of Anti-inflammatory and Antinociceptive Glycoterpenoids From the Flowers of Verbascum Lasianthum Boiss. Ex Bentham." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 444-50.
Kupeli E, Tatli II, Akdemir ZS, et al. Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. J Ethnopharmacol. 2007;110(3):444-50.
Kupeli, E., Tatli, I. I., Akdemir, Z. S., & Yesilada, E. (2007). Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. Journal of Ethnopharmacology, 110(3), 444-50.
Kupeli E, et al. Bioassay-guided Isolation of Anti-inflammatory and Antinociceptive Glycoterpenoids From the Flowers of Verbascum Lasianthum Boiss. Ex Bentham. J Ethnopharmacol. 2007 Apr 4;110(3):444-50. PubMed PMID: 17123759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. AU - Kupeli,Esra, AU - Tatli,I Irem, AU - Akdemir,Zeliha S, AU - Yesilada,Erdem, Y1 - 2006/10/19/ PY - 2006/01/06/received PY - 2006/09/29/revised PY - 2006/10/12/accepted PY - 2006/11/25/pubmed PY - 2007/6/15/medline PY - 2006/11/25/entrez SP - 444 EP - 50 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - Infusions of Verbascumlasianthum flowers have been used for hemorrhoids in Turkish folk medicine. In order to evaluate the scientific basis for this practice, in vivo anti-inflammatory and antinociceptive activities of Verbascum lasianthum Boiss. ex Bentham flowers were investigated. A methanolic extract of the flowers was shown to possess significant inhibitory activity in the carrageenan-induced hind paw edema model and in p-benzoquinone-induced writhings in mice. Through bioassay-guided fractionation and isolation procedures eight compounds, 6-O-(4'''-O-trans-p-coumaroyl)-alpha-L-rhamnopyranosylaucubin (1), 6-O-(4'''-O-trans-p-methoxycinnamoyl)-alpha-L-rhamnopyranosylaucubin (2), sinuatol (3), aucubin (4), geniposidic acid (5), catalpol (6), ajugol (7) and ilwensisaponin A (8) were isolated and their structures were elucidated by spectral techniques. An iridoid glucoside, aucubin (4) and a triterpenoid saponin, ilwensisaponin A (8) were found to possess significant antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity or gastric damage. Results of the present study support the continued and expanded utilization of plants employed in Turkish folk medicine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17123759/Bioassay_guided_isolation_of_anti_inflammatory_and_antinociceptive_glycoterpenoids_from_the_flowers_of_Verbascum_lasianthum_Boiss__ex_Bentham_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00518-6 DB - PRIME DP - Unbound Medicine ER -