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S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease.

Abstract

Recent epidemiological evidence showed that dietary fatty acids, antioxidants, and micronutrients appear to have a role in cognitive decline, and may permit a beneficial effect on the risk of dementia and predementia syndromes. We discussed in the present paper the issue of the suggested protective role of polyunsaturated fatty acids (PUFA) on Alzheimer's disease, mild cognitive impairment, and other predementia syndromes, supported by the findings of the Italian Longitudinal Study on Aging (ILSA) and other population-based studies. In particular, we discussed the possible metabolic link of plasma S-adenosylhomocysteine concentrations with PUFA erythrocyte composition in explaining this suggested protective role of fatty acids against dementia and predementia syndromes.

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  • Authors+Show Affiliations

    ,

    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy. geriat.dot@geriatria.uniba.it

    , , , ,

    Source

    Neurobiology of aging 29:3 2008 Mar pg 478-80

    MeSH

    Alzheimer Disease
    Dementia
    Early Diagnosis
    Fatty Acids, Unsaturated
    Humans
    S-Adenosylhomocysteine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17125887

    Citation

    Panza, Francesco, et al. "S-adenosylhomocysteine and Polyunsaturated Fatty Acid Metabolism in Predementia Syndromes and Alzheimer's Disease." Neurobiology of Aging, vol. 29, no. 3, 2008, pp. 478-80.
    Panza F, Capurso C, D'Introno A, et al. S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease. Neurobiol Aging. 2008;29(3):478-80.
    Panza, F., Capurso, C., D'Introno, A., Colacicco, A. M., Capurso, A., & Solfrizzi, V. (2008). S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease. Neurobiology of Aging, 29(3), pp. 478-80.
    Panza F, et al. S-adenosylhomocysteine and Polyunsaturated Fatty Acid Metabolism in Predementia Syndromes and Alzheimer's Disease. Neurobiol Aging. 2008;29(3):478-80. PubMed PMID: 17125887.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease. AU - Panza,Francesco, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna M, AU - Capurso,Antonio, AU - Solfrizzi,Vincenzo, Y1 - 2006/11/27/ PY - 2006/10/03/received PY - 2006/10/08/accepted PY - 2006/11/28/pubmed PY - 2008/3/28/medline PY - 2006/11/28/entrez SP - 478 EP - 80 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 29 IS - 3 N2 - Recent epidemiological evidence showed that dietary fatty acids, antioxidants, and micronutrients appear to have a role in cognitive decline, and may permit a beneficial effect on the risk of dementia and predementia syndromes. We discussed in the present paper the issue of the suggested protective role of polyunsaturated fatty acids (PUFA) on Alzheimer's disease, mild cognitive impairment, and other predementia syndromes, supported by the findings of the Italian Longitudinal Study on Aging (ILSA) and other population-based studies. In particular, we discussed the possible metabolic link of plasma S-adenosylhomocysteine concentrations with PUFA erythrocyte composition in explaining this suggested protective role of fatty acids against dementia and predementia syndromes. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/17125887/S_adenosylhomocysteine_and_polyunsaturated_fatty_acid_metabolism_in_predementia_syndromes_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00390-3 DB - PRIME DP - Unbound Medicine ER -