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Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.
J Ethnopharmacol. 2007 Apr 04; 110(3):464-70.JE

Abstract

The study was aimed at evaluating the antiulcer and antioxidant activities of 70% ethanolic axtract of leaves of Jasminum grandiflorum L. (JGLE). The leaves of Jasminum grandiflorum L. (Family: Oleaceae) is used in folk medicine for treating ulcerative stomatitis, skin diseases, ulcers, wounds, corns - a hard or soft hyperkeratosis of the sole of the human foot secondary to friction and pressure (Stedman's Medical Dictionary, 28th ed. Lippincott Williams & Wilkins, Philadelphia. p. 443), etc., Antiulcerogenic activity of JGLE (100 and 200 mg/kg, b.w., orally) was evaluated employing aspirin + pylorus ligation (APL) and alcohol (AL) induced acute gastric ulcer models and ulcer-healing activity using acetic acid-induced (AC) chronic ulcer model in rats. Both the antisecretory and cytoprotection hypothesis were evaluated. The antioxidant activity of JGLE has been assayed by using in vitro methods like 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH) assay, reductive ability, superoxide anion scavenging activity, nitric oxide scavenging activity and total phenolic content, in order to explain the role of antioxidant principles in the antiulcerogenic activity of the extract. There was a significant (P<0.01) dose-dependent decrease in the ulcerative lesion index produced by all the three models in rats as compared to the standard drug famotidine (20 mg/kg, b.w. orally). The reduction in gastric fluid volume, total acidity and an increase in the pH of the gastric fluid in APL rats proved the antisecretory activity of JGLE. Additionally, JGLE completely healed the ulcer within 20 days of treatment in AC model as evidenced by histopathological studies. Like antiulcer activity, the free radical scavenging activities of JGLE depends on concentration and increased with increasing amount of the extract. These results suggest that leaves of Jasminum grandiflorum possess potential antiulcer activity, which may be attributed to its antioxidant mechanism of action.

Authors+Show Affiliations

Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641044, India. umasaravanaprakash@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17125945

Citation

Umamaheswari, M, et al. "Antiulcer and in Vitro Antioxidant Activities of Jasminum Grandiflorum L." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 464-70.
Umamaheswari M, Asokkumar K, Rathidevi R, et al. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharmacol. 2007;110(3):464-70.
Umamaheswari, M., Asokkumar, K., Rathidevi, R., Sivashanmugam, A. T., Subhadradevi, V., & Ravi, T. K. (2007). Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. Journal of Ethnopharmacology, 110(3), 464-70.
Umamaheswari M, et al. Antiulcer and in Vitro Antioxidant Activities of Jasminum Grandiflorum L. J Ethnopharmacol. 2007 Apr 4;110(3):464-70. PubMed PMID: 17125945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. AU - Umamaheswari,M, AU - Asokkumar,K, AU - Rathidevi,R, AU - Sivashanmugam,A T, AU - Subhadradevi,V, AU - Ravi,T K, Y1 - 2006/10/21/ PY - 2006/02/24/received PY - 2006/09/30/revised PY - 2006/10/12/accepted PY - 2006/11/28/pubmed PY - 2007/6/15/medline PY - 2006/11/28/entrez SP - 464 EP - 70 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - The study was aimed at evaluating the antiulcer and antioxidant activities of 70% ethanolic axtract of leaves of Jasminum grandiflorum L. (JGLE). The leaves of Jasminum grandiflorum L. (Family: Oleaceae) is used in folk medicine for treating ulcerative stomatitis, skin diseases, ulcers, wounds, corns - a hard or soft hyperkeratosis of the sole of the human foot secondary to friction and pressure (Stedman's Medical Dictionary, 28th ed. Lippincott Williams & Wilkins, Philadelphia. p. 443), etc., Antiulcerogenic activity of JGLE (100 and 200 mg/kg, b.w., orally) was evaluated employing aspirin + pylorus ligation (APL) and alcohol (AL) induced acute gastric ulcer models and ulcer-healing activity using acetic acid-induced (AC) chronic ulcer model in rats. Both the antisecretory and cytoprotection hypothesis were evaluated. The antioxidant activity of JGLE has been assayed by using in vitro methods like 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH) assay, reductive ability, superoxide anion scavenging activity, nitric oxide scavenging activity and total phenolic content, in order to explain the role of antioxidant principles in the antiulcerogenic activity of the extract. There was a significant (P<0.01) dose-dependent decrease in the ulcerative lesion index produced by all the three models in rats as compared to the standard drug famotidine (20 mg/kg, b.w. orally). The reduction in gastric fluid volume, total acidity and an increase in the pH of the gastric fluid in APL rats proved the antisecretory activity of JGLE. Additionally, JGLE completely healed the ulcer within 20 days of treatment in AC model as evidenced by histopathological studies. Like antiulcer activity, the free radical scavenging activities of JGLE depends on concentration and increased with increasing amount of the extract. These results suggest that leaves of Jasminum grandiflorum possess potential antiulcer activity, which may be attributed to its antioxidant mechanism of action. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17125945/Antiulcer_and_in_vitro_antioxidant_activities_of_Jasminum_grandiflorum_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00520-4 DB - PRIME DP - Unbound Medicine ER -