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[Thyroiditis and gluten intolerance: extrapancreatic auto-immune diseases associated with type 1 diabetes].
Arch Pediatr 2007; 14(1):24-30AP

Abstract

OBJECTIVES

This study aimed at evaluating the screening of thyroïditis and coeliac disease, in a population of children and adolescents with type 1 diabetes, and at comparing the appearance of antibodies specific for these 2 diseases as a function of age.

PATIENTS AND METHODS

The study included 370 children and adolescents, 179 girls and 191 boys, aged 13.8 +/- 4.4 yr and with diabetes for 7.1 +/- 3.8 yr. Auto-immune thyroïditis was screened using antimicrosomal and antithyroglobulin auto-antibodies, at a mean rhythm of 3 tests per patient (1 every 2 yr), associated with dosages of TSH and FT4. Coeliac disease was screened using antigliadin (+/- antiendomysium) auto-antibodies, at a mean rhythm of 2 tests per patient, and was confirmed by duodenojejunal biopsy. Antithyroïd auto-antibodies were correlated with age following the "censured data analysis" type approach.

RESULTS

Antithyroïd autoantibodies were found in 42 patients (11.4%), of whom 9 were treated for hypothyroïdism and 1 for Basedow disease, and coeliac disease autoantibodies were found in 9 patients (3.2% of tested patients). The cumulated frequency of antithyroïd auto-antibodies increased regularly with age and was significantly higher in girls, reaching 28% in girls and 12% in boys around 18 yr of age. As a consequence of this evolution, antithyroïd auto-antibodies were frequently found at the time of diagnosis of diabetes when it declared after 10 yr of age, while they often became positive secondarily when diabetes occurred before 10 yr of age. Coeliac disease specific auto-antibodies appeared much earlier and were found at the time of diagnosis of diabetes or at the first screening test.

CONCLUSION

Antithyroïd autoantibodies are increasingly frequent with age in children with type 1 diabetes, and become very elevated in girls. The rhythm for screening should be adapted to this evolution of autoantibodies with age, which is very different between thyroïditis and coeliac disease.

Authors+Show Affiliations

Diabète de l'enfant et de l'adolescent, fédération de pédiatrie, APHP, hôpital Necker-Enfants-malades, 149, rue de Sèvres, 75343 Paris cedex 15, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

17125979

Citation

Faesch, S, et al. "[Thyroiditis and Gluten Intolerance: Extrapancreatic Auto-immune Diseases Associated With Type 1 Diabetes]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 14, no. 1, 2007, pp. 24-30.
Faesch S, Jennane F, Izembart I, et al. [Thyroiditis and gluten intolerance: extrapancreatic auto-immune diseases associated with type 1 diabetes]. Arch Pediatr. 2007;14(1):24-30.
Faesch, S., Jennane, F., Izembart, I., Chatenoud, L., Taupin, P., Martin, D., ... Robert, J. J. (2007). [Thyroiditis and gluten intolerance: extrapancreatic auto-immune diseases associated with type 1 diabetes]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 14(1), pp. 24-30.
Faesch S, et al. [Thyroiditis and Gluten Intolerance: Extrapancreatic Auto-immune Diseases Associated With Type 1 Diabetes]. Arch Pediatr. 2007;14(1):24-30. PubMed PMID: 17125979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Thyroiditis and gluten intolerance: extrapancreatic auto-immune diseases associated with type 1 diabetes]. AU - Faesch,S, AU - Jennane,F, AU - Izembart,I, AU - Chatenoud,L, AU - Taupin,P, AU - Martin,D, AU - Polak,M, AU - Robert,J-J, Y1 - 2006/11/27/ PY - 2006/03/01/received PY - 2006/09/20/accepted PY - 2006/11/28/pubmed PY - 2007/4/7/medline PY - 2006/11/28/entrez SP - 24 EP - 30 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 14 IS - 1 N2 - OBJECTIVES: This study aimed at evaluating the screening of thyroïditis and coeliac disease, in a population of children and adolescents with type 1 diabetes, and at comparing the appearance of antibodies specific for these 2 diseases as a function of age. PATIENTS AND METHODS: The study included 370 children and adolescents, 179 girls and 191 boys, aged 13.8 +/- 4.4 yr and with diabetes for 7.1 +/- 3.8 yr. Auto-immune thyroïditis was screened using antimicrosomal and antithyroglobulin auto-antibodies, at a mean rhythm of 3 tests per patient (1 every 2 yr), associated with dosages of TSH and FT4. Coeliac disease was screened using antigliadin (+/- antiendomysium) auto-antibodies, at a mean rhythm of 2 tests per patient, and was confirmed by duodenojejunal biopsy. Antithyroïd auto-antibodies were correlated with age following the "censured data analysis" type approach. RESULTS: Antithyroïd autoantibodies were found in 42 patients (11.4%), of whom 9 were treated for hypothyroïdism and 1 for Basedow disease, and coeliac disease autoantibodies were found in 9 patients (3.2% of tested patients). The cumulated frequency of antithyroïd auto-antibodies increased regularly with age and was significantly higher in girls, reaching 28% in girls and 12% in boys around 18 yr of age. As a consequence of this evolution, antithyroïd auto-antibodies were frequently found at the time of diagnosis of diabetes when it declared after 10 yr of age, while they often became positive secondarily when diabetes occurred before 10 yr of age. Coeliac disease specific auto-antibodies appeared much earlier and were found at the time of diagnosis of diabetes or at the first screening test. CONCLUSION: Antithyroïd autoantibodies are increasingly frequent with age in children with type 1 diabetes, and become very elevated in girls. The rhythm for screening should be adapted to this evolution of autoantibodies with age, which is very different between thyroïditis and coeliac disease. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/17125979/[Thyroiditis_and_gluten_intolerance:_extrapancreatic_auto_immune_diseases_associated_with_type_1_diabetes]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(06)00516-1 DB - PRIME DP - Unbound Medicine ER -