Tags

Type your tag names separated by a space and hit enter

Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis.
Ann Diagn Pathol. 2006 Dec; 10(6):363-6.AD

Abstract

BACKGROUND

Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney is a rare and aggressive tumor. It has a rapid clinical progression with early metastasis and death. Few cases with documented t(11;22) have been reported in the literature.

CASE PRESENTATION

We report a case of EWS/PNET of the kidney in a 26-year-old woman with widespread metastasis at initial presentation. The tumor cells showed strong expression for CD99 and FLI-1 monoclonal antibodies and polyclonal antibodies and were negative for WT1 and numerous other markers. The diagnosis was subsequently confirmed by demonstrating t(11;22)(q24;q12) using cytogenetic karyotyping and fluorescence in situ hybridization.

CONCLUSIONS

Due to the different prognosis and management between EWS/PNET and other primary renal neoplasms with similar morphology, a histopathologic diagnosis with extreme accuracy should be made. Cytogenetic analysis is an important supportive tool to immunohistochemistry in making the final diagnosis.

Authors+Show Affiliations

Department of Surgical Pathology and Laboratory Medicine, Buffalo General Hospital, Buffalo, NY 14263, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17126256

Citation

Saxena, Rakhee, et al. "Ewing Sarcoma/primitive Neuroectodermal Tumor of the Kidney: a Case Report. Diagnosed By Immunohistochemistry and Molecular Analysis." Annals of Diagnostic Pathology, vol. 10, no. 6, 2006, pp. 363-6.
Saxena R, Sait S, Mhawech-Fauceglia P. Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis. Ann Diagn Pathol. 2006;10(6):363-6.
Saxena, R., Sait, S., & Mhawech-Fauceglia, P. (2006). Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis. Annals of Diagnostic Pathology, 10(6), 363-6.
Saxena R, Sait S, Mhawech-Fauceglia P. Ewing Sarcoma/primitive Neuroectodermal Tumor of the Kidney: a Case Report. Diagnosed By Immunohistochemistry and Molecular Analysis. Ann Diagn Pathol. 2006;10(6):363-6. PubMed PMID: 17126256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis. AU - Saxena,Rakhee, AU - Sait,Sheila, AU - Mhawech-Fauceglia,Paulette, PY - 2006/11/28/pubmed PY - 2007/1/17/medline PY - 2006/11/28/entrez SP - 363 EP - 6 JF - Annals of diagnostic pathology JO - Ann Diagn Pathol VL - 10 IS - 6 N2 - BACKGROUND: Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney is a rare and aggressive tumor. It has a rapid clinical progression with early metastasis and death. Few cases with documented t(11;22) have been reported in the literature. CASE PRESENTATION: We report a case of EWS/PNET of the kidney in a 26-year-old woman with widespread metastasis at initial presentation. The tumor cells showed strong expression for CD99 and FLI-1 monoclonal antibodies and polyclonal antibodies and were negative for WT1 and numerous other markers. The diagnosis was subsequently confirmed by demonstrating t(11;22)(q24;q12) using cytogenetic karyotyping and fluorescence in situ hybridization. CONCLUSIONS: Due to the different prognosis and management between EWS/PNET and other primary renal neoplasms with similar morphology, a histopathologic diagnosis with extreme accuracy should be made. Cytogenetic analysis is an important supportive tool to immunohistochemistry in making the final diagnosis. SN - 1092-9134 UR - https://www.unboundmedicine.com/medline/citation/17126256/Ewing_sarcoma/primitive_neuroectodermal_tumor_of_the_kidney:_a_case_report__Diagnosed_by_immunohistochemistry_and_molecular_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1092-9134(05)00185-1 DB - PRIME DP - Unbound Medicine ER -