Tags

Type your tag names separated by a space and hit enter

The Mayo Clinic quadratic equation improves the prediction of glomerular filtration rate in diabetic subjects.
Nephrol Dial Transplant. 2007 Mar; 22(3):813-8.ND

Abstract

BACKGROUND

Although recommended, both the Cockcroft and Gault formula (CG) and the modification of diet in renal disease (MDRD) equation are not ideally predictive of glomerular filtration rate (GFR) in diabetic subjects; we tested whether the new Mayo Clinic Quadratic (MCQ) equation performed better.

METHODS

In 200 diabetic subjects with a wide range of renal function, GFR was measured by 51Cr-EDTA clearance, and compared with the results of the three predictive equations by regression analysis and Bland and Altman procedures. The correlations with body mass index, age and albumin excretion rates were tested. The precisions (absolute difference as percentage), diagnostic accuracies [receiver operating characteristic (ROC) curves for the diagnosis of moderate and severe chronic kidney disease (CKD)], and the results of stratification according to the KDOQ classification were compared.

RESULTS

The CG and MCQ overestimated mean GFR, whereas the MDRD underestimated it. Correlation coefficients and areas under the ROC curves were better for the MDRD and the MCQ as compared with the CG, which was biased by body weight (+30% overestimation in obese diabetic subjects). The absolute differences with true GFR were slightly lower for the MDRD than the MCQ, and both better than the CG. Both the MDRD and MCQ correctly stratified 65% of the subjects (CG: 55%, P<0.05). In contrast with the MDRD, the MCQ did not underestimate normal GFR, and its performance for stratification was uniformly good over a wide GFR range.

CONCLUSIONS

In diabetic subjects, the MCQ has a similar diagnostic performance to the MDRD, but it does not underestimate normal GFR, which is an important advantage.

Authors+Show Affiliations

Université de Bordeaux 2--Victor Segalen, 33000 Bordeaux, France. vincent.rigalleau@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17127699

Citation

Rigalleau, Vincent, et al. "The Mayo Clinic Quadratic Equation Improves the Prediction of Glomerular Filtration Rate in Diabetic Subjects." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 22, no. 3, 2007, pp. 813-8.
Rigalleau V, Lasseur C, Raffaitin C, et al. The Mayo Clinic quadratic equation improves the prediction of glomerular filtration rate in diabetic subjects. Nephrol Dial Transplant. 2007;22(3):813-8.
Rigalleau, V., Lasseur, C., Raffaitin, C., Perlemoine, C., Barthe, N., Chauveau, P., Combe, C., & Gin, H. (2007). The Mayo Clinic quadratic equation improves the prediction of glomerular filtration rate in diabetic subjects. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 22(3), 813-8.
Rigalleau V, et al. The Mayo Clinic Quadratic Equation Improves the Prediction of Glomerular Filtration Rate in Diabetic Subjects. Nephrol Dial Transplant. 2007;22(3):813-8. PubMed PMID: 17127699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Mayo Clinic quadratic equation improves the prediction of glomerular filtration rate in diabetic subjects. AU - Rigalleau,Vincent, AU - Lasseur,Catherine, AU - Raffaitin,Christelle, AU - Perlemoine,Caroline, AU - Barthe,Nicole, AU - Chauveau,Philippe, AU - Combe,Christian, AU - Gin,Henri, Y1 - 2006/11/24/ PY - 2006/11/28/pubmed PY - 2007/5/2/medline PY - 2006/11/28/entrez SP - 813 EP - 8 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 22 IS - 3 N2 - BACKGROUND: Although recommended, both the Cockcroft and Gault formula (CG) and the modification of diet in renal disease (MDRD) equation are not ideally predictive of glomerular filtration rate (GFR) in diabetic subjects; we tested whether the new Mayo Clinic Quadratic (MCQ) equation performed better. METHODS: In 200 diabetic subjects with a wide range of renal function, GFR was measured by 51Cr-EDTA clearance, and compared with the results of the three predictive equations by regression analysis and Bland and Altman procedures. The correlations with body mass index, age and albumin excretion rates were tested. The precisions (absolute difference as percentage), diagnostic accuracies [receiver operating characteristic (ROC) curves for the diagnosis of moderate and severe chronic kidney disease (CKD)], and the results of stratification according to the KDOQ classification were compared. RESULTS: The CG and MCQ overestimated mean GFR, whereas the MDRD underestimated it. Correlation coefficients and areas under the ROC curves were better for the MDRD and the MCQ as compared with the CG, which was biased by body weight (+30% overestimation in obese diabetic subjects). The absolute differences with true GFR were slightly lower for the MDRD than the MCQ, and both better than the CG. Both the MDRD and MCQ correctly stratified 65% of the subjects (CG: 55%, P<0.05). In contrast with the MDRD, the MCQ did not underestimate normal GFR, and its performance for stratification was uniformly good over a wide GFR range. CONCLUSIONS: In diabetic subjects, the MCQ has a similar diagnostic performance to the MDRD, but it does not underestimate normal GFR, which is an important advantage. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/17127699/The_Mayo_Clinic_quadratic_equation_improves_the_prediction_of_glomerular_filtration_rate_in_diabetic_subjects_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfl649 DB - PRIME DP - Unbound Medicine ER -