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[Studies of the properties of tablets made from directly compressible starch and its mixtures with directly compressible lactose].
Ceska Slov Farm. 2006 Sep; 55(5):236-41.CS

Abstract

The paper studies the strength and disintegration time of compacts made from directly compressible Starch 1500 and its mixtures with directly compressible lactose Pharmatosa DCL 15 in different relative proportions in dependence on the added lubricant magnesium stearate and the model active ingredient ascorbic acid. The dry binders under study differ in their mechanisms of compression and thus in their sensitivity to the addition of the lubricant, which is manifested in decreased strengths of the compacts as well as the mechanism of disintegration of the compacts. The mixtures of substances under study were in the relative representations of 1:3, 1:1 and 3:1. The employed concentration of the lubricant magnesium stearate was 0.4%, that of ascorbic acid, 50%. The study has confirmed and quantitatively evaluated the sensitivity of directly compressible starch to the addition of magnesium stearate. A higher share of directly compressible lactose in the mixture decreased the sensitivity of tableting material to the addition of the lubricant and shortened disintegration time. The presence of stearate did not negatively influence disintegration time, with an exception of the mixture of Starch 1500 and Pharmatosa DCL 15 1:3. An addition of the model active ingredient ascorbic acid decreased the strength of the compacts and shortened the disintegration time in all tableting materials tested.

Authors+Show Affiliations

Muzíková J
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie. muzikova@faf.cuni.cz
Moucková E
No affiliation info available

MeSH

LactosePharmaceutic AidsStarchTabletsTechnology, Pharmaceutical

Pub Type(s)

English Abstract
Journal Article

Language

cze

PubMed ID

17128594

Citation

Muzíková, J, and E Moucková. "[Studies of the Properties of Tablets Made From Directly Compressible Starch and Its Mixtures With Directly Compressible Lactose]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 55, no. 5, 2006, pp. 236-41.
Muzíková J, Moucková E. [Studies of the properties of tablets made from directly compressible starch and its mixtures with directly compressible lactose]. Ceska Slov Farm. 2006;55(5):236-41.
Muzíková, J., & Moucková, E. (2006). [Studies of the properties of tablets made from directly compressible starch and its mixtures with directly compressible lactose]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 55(5), 236-41.
Muzíková J, Moucková E. [Studies of the Properties of Tablets Made From Directly Compressible Starch and Its Mixtures With Directly Compressible Lactose]. Ceska Slov Farm. 2006;55(5):236-41. PubMed PMID: 17128594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies of the properties of tablets made from directly compressible starch and its mixtures with directly compressible lactose]. AU - Muzíková,J, AU - Moucková,E, PY - 2006/11/30/pubmed PY - 2007/2/14/medline PY - 2006/11/30/entrez SP - 236 EP - 41 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 55 IS - 5 N2 - The paper studies the strength and disintegration time of compacts made from directly compressible Starch 1500 and its mixtures with directly compressible lactose Pharmatosa DCL 15 in different relative proportions in dependence on the added lubricant magnesium stearate and the model active ingredient ascorbic acid. The dry binders under study differ in their mechanisms of compression and thus in their sensitivity to the addition of the lubricant, which is manifested in decreased strengths of the compacts as well as the mechanism of disintegration of the compacts. The mixtures of substances under study were in the relative representations of 1:3, 1:1 and 3:1. The employed concentration of the lubricant magnesium stearate was 0.4%, that of ascorbic acid, 50%. The study has confirmed and quantitatively evaluated the sensitivity of directly compressible starch to the addition of magnesium stearate. A higher share of directly compressible lactose in the mixture decreased the sensitivity of tableting material to the addition of the lubricant and shortened disintegration time. The presence of stearate did not negatively influence disintegration time, with an exception of the mixture of Starch 1500 and Pharmatosa DCL 15 1:3. An addition of the model active ingredient ascorbic acid decreased the strength of the compacts and shortened the disintegration time in all tableting materials tested. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/17128594/[Studies_of_the_properties_of_tablets_made_from_directly_compressible_starch_and_its_mixtures_with_directly_compressible_lactose]_ DB - PRIME DP - Unbound Medicine ER -