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Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women.
J Med Assoc Thai. 2006 Oct; 89(10):1579-83.JM

Abstract

OBJECTIVE

Adiponectin is a recently discovered hormone secreted by adipocytes. Adiponectin plays an important role in the regulation of insulin sensitivity as well as the propensity to inflammation and atherosclerosis. In the present study, the authors explore the relationship between adiponectin and bone mass in premenopausal women. The relationship of fat mass compared to lean body mass to bone mass was also investigated

MATERIAL AND METHOD

Two hundred premenopausal women aged between 20 and 40 years were studied. Bone mineral density (BMD) was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Serum adiponectin concentrations were measured by radioimmunoassay.

RESULTS

At the lumbar spines, factors associated with BMD were age (p < 0.01) and lean body mass (p < 0.001). No independent association with fat mass was demonstrated Likewise, at the femoral neck, only lean body mass was related to BMD (p < 0. 01). In terms of the relation of serum adiponectin to BMD, no association of serum adiponectin to BMD at the lumbar spines or femoral neck was found

CONCLUSION

Altogether, the present findings do not suggest the independent role of adiponectin in the accrual of bone mass in females, although such a role still cannot be excluded in men or postmenopausal women.

Authors+Show Affiliations

Research Center, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17128830

Citation

Chanprasertyothin, Suwannee, et al. "Relationship of Body Composition and Circulatory Adiponectin to Bone Mineral Density in Young Premenopausal Women." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 89, no. 10, 2006, pp. 1579-83.
Chanprasertyothin S, Saetung S, Payattikul P, et al. Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women. J Med Assoc Thai. 2006;89(10):1579-83.
Chanprasertyothin, S., Saetung, S., Payattikul, P., Rajatanavin, R., & Ongphiphadhanakul, B. (2006). Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 89(10), 1579-83.
Chanprasertyothin S, et al. Relationship of Body Composition and Circulatory Adiponectin to Bone Mineral Density in Young Premenopausal Women. J Med Assoc Thai. 2006;89(10):1579-83. PubMed PMID: 17128830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women. AU - Chanprasertyothin,Suwannee, AU - Saetung,Sunee, AU - Payattikul,Penpan, AU - Rajatanavin,Rajata, AU - Ongphiphadhanakul,Boonsong, PY - 2006/11/30/pubmed PY - 2007/10/24/medline PY - 2006/11/30/entrez SP - 1579 EP - 83 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 89 IS - 10 N2 - OBJECTIVE: Adiponectin is a recently discovered hormone secreted by adipocytes. Adiponectin plays an important role in the regulation of insulin sensitivity as well as the propensity to inflammation and atherosclerosis. In the present study, the authors explore the relationship between adiponectin and bone mass in premenopausal women. The relationship of fat mass compared to lean body mass to bone mass was also investigated MATERIAL AND METHOD: Two hundred premenopausal women aged between 20 and 40 years were studied. Bone mineral density (BMD) was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Serum adiponectin concentrations were measured by radioimmunoassay. RESULTS: At the lumbar spines, factors associated with BMD were age (p < 0.01) and lean body mass (p < 0.001). No independent association with fat mass was demonstrated Likewise, at the femoral neck, only lean body mass was related to BMD (p < 0. 01). In terms of the relation of serum adiponectin to BMD, no association of serum adiponectin to BMD at the lumbar spines or femoral neck was found CONCLUSION: Altogether, the present findings do not suggest the independent role of adiponectin in the accrual of bone mass in females, although such a role still cannot be excluded in men or postmenopausal women. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/17128830/Relationship_of_body_composition_and_circulatory_adiponectin_to_bone_mineral_density_in_young_premenopausal_women_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -