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Weight cycling and risk of gallstone disease in men.

Abstract

BACKGROUND

The long-term effect of repeated intentional weight loss and weight regain on the risk of gallstone disease in men is not clear.

METHODS

Participants in the Health Professionals Follow-up Study provided information on intentional weight loss during the previous 4 years in 1992. Weight cyclers were men who had intentional weight loss and weight regain. Men free of gallstone disease at baseline were followed from 1992 to 2002. On biennial questionnaires the participants reported newly diagnosed gallstone disease.

RESULTS

During 264,760 person-years of follow-up we ascertained 1222 cases of symptomatic gallstones. We examined the effect of weight cycling on the risk of gallstone disease. The multivariate relative risk of weight cyclers, compared with weight maintainers, after adjusting for potential confounding variables, including body mass index, was 1.11 (95% confidence interval [CI], 0.94-1.31) in light cyclers, 1.18 (95% CI, 0.97-1.43) in moderate cyclers, and 1.42 (95% CI, 1.11-1.81) in severe cyclers. We further examined the effect of number of cycling episodes. Among weight cyclers, the relative risk associated with having more than 1 weight cycle, compared with weight maintainers, was 1.10 (95% CI, 0.88-1.37) in light cyclers, 1.28 (95% CI, 1.03-1.59) in moderate cyclers, and 1.51 (95% CI, 1.13-2.02) in severe cyclers.

CONCLUSIONS

Our findings suggest that weight cycling, independent of body mass index, may increase the risk of gallstone disease in men. Larger weight fluctuation and more weight cycles are associated with greater risk.

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  • Authors+Show Affiliations

    ,

    Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536-0298, USA. hpcjt@channing.harvard.edu

    , ,

    Source

    Archives of internal medicine 166:21 2006 Nov 27 pg 2369-74

    MeSH

    Adult
    Aged
    Algorithms
    Body Mass Index
    Body Weight
    Cohort Studies
    Confounding Factors (Epidemiology)
    Gallstones
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    United States
    Weight Gain
    Weight Loss

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    17130391

    Citation

    Tsai, Chung-Jyi, et al. "Weight Cycling and Risk of Gallstone Disease in Men." Archives of Internal Medicine, vol. 166, no. 21, 2006, pp. 2369-74.
    Tsai CJ, Leitzmann MF, Willett WC, et al. Weight cycling and risk of gallstone disease in men. Arch Intern Med. 2006;166(21):2369-74.
    Tsai, C. J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L. (2006). Weight cycling and risk of gallstone disease in men. Archives of Internal Medicine, 166(21), pp. 2369-74.
    Tsai CJ, et al. Weight Cycling and Risk of Gallstone Disease in Men. Arch Intern Med. 2006 Nov 27;166(21):2369-74. PubMed PMID: 17130391.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Weight cycling and risk of gallstone disease in men. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2006/11/30/pubmed PY - 2007/1/16/medline PY - 2006/11/30/entrez SP - 2369 EP - 74 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 21 N2 - BACKGROUND: The long-term effect of repeated intentional weight loss and weight regain on the risk of gallstone disease in men is not clear. METHODS: Participants in the Health Professionals Follow-up Study provided information on intentional weight loss during the previous 4 years in 1992. Weight cyclers were men who had intentional weight loss and weight regain. Men free of gallstone disease at baseline were followed from 1992 to 2002. On biennial questionnaires the participants reported newly diagnosed gallstone disease. RESULTS: During 264,760 person-years of follow-up we ascertained 1222 cases of symptomatic gallstones. We examined the effect of weight cycling on the risk of gallstone disease. The multivariate relative risk of weight cyclers, compared with weight maintainers, after adjusting for potential confounding variables, including body mass index, was 1.11 (95% confidence interval [CI], 0.94-1.31) in light cyclers, 1.18 (95% CI, 0.97-1.43) in moderate cyclers, and 1.42 (95% CI, 1.11-1.81) in severe cyclers. We further examined the effect of number of cycling episodes. Among weight cyclers, the relative risk associated with having more than 1 weight cycle, compared with weight maintainers, was 1.10 (95% CI, 0.88-1.37) in light cyclers, 1.28 (95% CI, 1.03-1.59) in moderate cyclers, and 1.51 (95% CI, 1.13-2.02) in severe cyclers. CONCLUSIONS: Our findings suggest that weight cycling, independent of body mass index, may increase the risk of gallstone disease in men. Larger weight fluctuation and more weight cycles are associated with greater risk. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/17130391/Weight_cycling_and_risk_of_gallstone_disease_in_men_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.21.2369 DB - PRIME DP - Unbound Medicine ER -