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Genetic testing for colon cancer.
Nat Clin Pract Gastroenterol Hepatol. 2006 Dec; 3(12):670-9.NC

Abstract

Colon cancer remains the third leading cause of death due to cancer in the US, where it affected more than 145,000 individuals in 2005. Up to 30% of these cases exhibit familial clustering, which means that tens of thousands of individuals have a disease with a potentially definable genetic component. Approximately 3-5% of colon cancers are associated with high-risk, inherited colon cancer syndromes. Identification of the genes that cause these colon cancer syndromes, coupled with additional insights into their clinical course, has led to the development of specific management guidelines--and genetic tests--that can diagnose these familial disorders. These guidelines can be life-saving, not only for the affected patient, but also for their family members.

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Publisher Full Text

Authors+Show Affiliations

Kaz AM
University of Washington and Fred Hutchinson Cancer Research Center in Seattle, WA 98195, USA.
Brentnall TA
No affiliation info available

MeSH

Adenomatous Polyposis ColiColonic NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA Mutational AnalysisGenetic CounselingGenetic TestingHamartoma Syndrome, MultipleHumansInformed ConsentPeutz-Jeghers Syndrome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17130877

Citation

Kaz, Andrew M., and Teresa A. Brentnall. "Genetic Testing for Colon Cancer." Nature Clinical Practice. Gastroenterology & Hepatology, vol. 3, no. 12, 2006, pp. 670-9.
Kaz AM, Brentnall TA. Genetic testing for colon cancer. Nat Clin Pract Gastroenterol Hepatol. 2006;3(12):670-9.
Kaz, A. M., & Brentnall, T. A. (2006). Genetic testing for colon cancer. Nature Clinical Practice. Gastroenterology & Hepatology, 3(12), 670-9.
Kaz AM, Brentnall TA. Genetic Testing for Colon Cancer. Nat Clin Pract Gastroenterol Hepatol. 2006;3(12):670-9. PubMed PMID: 17130877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic testing for colon cancer. AU - Kaz,Andrew M, AU - Brentnall,Teresa A, PY - 2006/01/27/received PY - 2006/09/05/accepted PY - 2006/11/30/pubmed PY - 2006/12/23/medline PY - 2006/11/30/entrez SP - 670 EP - 9 JF - Nature clinical practice. Gastroenterology & hepatology JO - Nat Clin Pract Gastroenterol Hepatol VL - 3 IS - 12 N2 - Colon cancer remains the third leading cause of death due to cancer in the US, where it affected more than 145,000 individuals in 2005. Up to 30% of these cases exhibit familial clustering, which means that tens of thousands of individuals have a disease with a potentially definable genetic component. Approximately 3-5% of colon cancers are associated with high-risk, inherited colon cancer syndromes. Identification of the genes that cause these colon cancer syndromes, coupled with additional insights into their clinical course, has led to the development of specific management guidelines--and genetic tests--that can diagnose these familial disorders. These guidelines can be life-saving, not only for the affected patient, but also for their family members. SN - 1743-4386 UR - https://www.unboundmedicine.com/medline/citation/17130877/Genetic_testing_for_colon_cancer_ L2 - http://dx.doi.org/10.1038/ncpgasthep0663 DB - PRIME DP - Unbound Medicine ER -