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Risk-factor profile for the incidence of subarachnoid and intracerebral haemorrhage, cerebral infarction, and unspecified stroke during 21 years' follow-up in men.
Scand J Public Health 2006; 34(6):589-97SJ

Abstract

AIMS

To study the risk-factor profile for the incidence of non-fatal and fatal stroke among middle-aged men according to the stroke subtypes subarachnoid or intracerebral haemorrhage, cerebral infarction, and unspecified stroke.

METHODS

The study design is a prospective cohort study. A total of 16,209 men aged 40-49 years resident in Oslo were screened for cardiovascular disease risk factors in 1972-73. Of these, 14,403 men had no cardiovascular symptoms or diseases or diabetes. The incidence of stroke after 21 years of follow-up of all men was extracted from hospital records and linkage to Statistics Norway.

RESULTS

A total of 429 non-fatal and 107 fatal stroke events were registered. Case fatality within 28 days (number and percentage of cases) was 51% (41, 7.7%) for subarachnoid haemorrhage, 39% (67, 12.6%) for cerebral haemorrhage, 10% (246, 46.3%) for cerebral infarct, and 19% (177, 33.4%) for unspecified stroke. Risk of stroke (not subarachnoid haemorrhage) increased with the presence of symptoms or a history of cardiovascular disease or diabetes. In multivariate analysis of men without CVD or diabetes, high blood pressure was a risk factor for all subtypes of stroke; furthermore, daily smoking was a risk factor for all subtypes except subarachnoid haemorrhage. Serum cholesterol and glucose concentrations and height (inverse association) were independently associated with cerebral infarction. Smoking was a significantly stronger predictor of fatal than non-fatal events.

CONCLUSIONS

The risk-factor profile differed according to the underlying subtype of stroke. Cerebral infarction clearly shared with myocardial infarction the classical risk factors, including non-fasting glucose concentration.

Authors+Show Affiliations

Norwegian Knowledge Centre for the Health Services, Oslo, Norway. Lise.Lund.Haheim@nokc.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17132592

Citation

Lund Håheim, Lise, et al. "Risk-factor Profile for the Incidence of Subarachnoid and Intracerebral Haemorrhage, Cerebral Infarction, and Unspecified Stroke During 21 Years' Follow-up in Men." Scandinavian Journal of Public Health, vol. 34, no. 6, 2006, pp. 589-97.
Lund Håheim L, Holme I, Hjermann I, et al. Risk-factor profile for the incidence of subarachnoid and intracerebral haemorrhage, cerebral infarction, and unspecified stroke during 21 years' follow-up in men. Scand J Public Health. 2006;34(6):589-97.
Lund Håheim, L., Holme, I., Hjermann, I., & Tonstad, S. (2006). Risk-factor profile for the incidence of subarachnoid and intracerebral haemorrhage, cerebral infarction, and unspecified stroke during 21 years' follow-up in men. Scandinavian Journal of Public Health, 34(6), pp. 589-97.
Lund Håheim L, et al. Risk-factor Profile for the Incidence of Subarachnoid and Intracerebral Haemorrhage, Cerebral Infarction, and Unspecified Stroke During 21 Years' Follow-up in Men. Scand J Public Health. 2006;34(6):589-97. PubMed PMID: 17132592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk-factor profile for the incidence of subarachnoid and intracerebral haemorrhage, cerebral infarction, and unspecified stroke during 21 years' follow-up in men. AU - Lund Håheim,Lise, AU - Holme,Ingar, AU - Hjermann,Ingvar, AU - Tonstad,Serena, PY - 2006/11/30/pubmed PY - 2007/1/5/medline PY - 2006/11/30/entrez SP - 589 EP - 97 JF - Scandinavian journal of public health JO - Scand J Public Health VL - 34 IS - 6 N2 - AIMS: To study the risk-factor profile for the incidence of non-fatal and fatal stroke among middle-aged men according to the stroke subtypes subarachnoid or intracerebral haemorrhage, cerebral infarction, and unspecified stroke. METHODS: The study design is a prospective cohort study. A total of 16,209 men aged 40-49 years resident in Oslo were screened for cardiovascular disease risk factors in 1972-73. Of these, 14,403 men had no cardiovascular symptoms or diseases or diabetes. The incidence of stroke after 21 years of follow-up of all men was extracted from hospital records and linkage to Statistics Norway. RESULTS: A total of 429 non-fatal and 107 fatal stroke events were registered. Case fatality within 28 days (number and percentage of cases) was 51% (41, 7.7%) for subarachnoid haemorrhage, 39% (67, 12.6%) for cerebral haemorrhage, 10% (246, 46.3%) for cerebral infarct, and 19% (177, 33.4%) for unspecified stroke. Risk of stroke (not subarachnoid haemorrhage) increased with the presence of symptoms or a history of cardiovascular disease or diabetes. In multivariate analysis of men without CVD or diabetes, high blood pressure was a risk factor for all subtypes of stroke; furthermore, daily smoking was a risk factor for all subtypes except subarachnoid haemorrhage. Serum cholesterol and glucose concentrations and height (inverse association) were independently associated with cerebral infarction. Smoking was a significantly stronger predictor of fatal than non-fatal events. CONCLUSIONS: The risk-factor profile differed according to the underlying subtype of stroke. Cerebral infarction clearly shared with myocardial infarction the classical risk factors, including non-fasting glucose concentration. SN - 1403-4948 UR - https://www.unboundmedicine.com/medline/citation/17132592/Risk_factor_profile_for_the_incidence_of_subarachnoid_and_intracerebral_haemorrhage_cerebral_infarction_and_unspecified_stroke_during_21_years'_follow_up_in_men_ L2 - http://journals.sagepub.com/doi/full/10.1080/14034940600731523?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -