Tags

Type your tag names separated by a space and hit enter

Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease.
Chin Med J (Engl). 2006 Nov 20; 119(22):1866-70.CM

Abstract

BACKGROUND

Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity (baPWV) and endothelial function in CAD patients.

METHODS

Thirty-three patients with CAD and thirty control subjects were recruited for this study. baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer (PWV/ABI, Colin Co. Ltd., Komaki, Japan). Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device.

RESULTS

baPWV was increased in CAD patients compared with control subjects [(1756.1 +/- 253.1) cm/s vs (1495.3 +/- 202.3) cm/s, P < 0.01]. FMD was significantly reduced in CAD patients compared with control subjects [(5.2 +/- 2.1)% vs (11.1 +/- 4.4)%, P < 0.01]. baPWV correlated with FMD (r = -0.68, P < 0.001). The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group.

CONCLUSIONS

CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function.

Authors+Show Affiliations

Department of Ultrasound, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17134584

Citation

Liu, Dong-hong, et al. "Increased Brachial-ankle Pulse Wave Velocity Is Associated With Impaired Endothelial Function in Patients With Coronary Artery Disease." Chinese Medical Journal, vol. 119, no. 22, 2006, pp. 1866-70.
Liu DH, Wang Y, Liao XX, et al. Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease. Chin Med J. 2006;119(22):1866-70.
Liu, D. H., Wang, Y., Liao, X. X., Xu, M. G., Wang, J. M., Yang, Z., Chen, L., Lü, M. D., Lu, K., & Tao, J. (2006). Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease. Chinese Medical Journal, 119(22), 1866-70.
Liu DH, et al. Increased Brachial-ankle Pulse Wave Velocity Is Associated With Impaired Endothelial Function in Patients With Coronary Artery Disease. Chin Med J. 2006 Nov 20;119(22):1866-70. PubMed PMID: 17134584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease. AU - Liu,Dong-hong, AU - Wang,Yan, AU - Liao,Xin-xue, AU - Xu,Ming-guo, AU - Wang,Jie-mei, AU - Yang,Zhen, AU - Chen,Long, AU - Lü,Ming-de, AU - Lu,Kun, AU - Tao,Jun, PY - 2006/12/1/pubmed PY - 2007/1/18/medline PY - 2006/12/1/entrez SP - 1866 EP - 70 JF - Chinese medical journal JO - Chin. Med. J. VL - 119 IS - 22 N2 - BACKGROUND: Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity (baPWV) and endothelial function in CAD patients. METHODS: Thirty-three patients with CAD and thirty control subjects were recruited for this study. baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer (PWV/ABI, Colin Co. Ltd., Komaki, Japan). Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device. RESULTS: baPWV was increased in CAD patients compared with control subjects [(1756.1 +/- 253.1) cm/s vs (1495.3 +/- 202.3) cm/s, P < 0.01]. FMD was significantly reduced in CAD patients compared with control subjects [(5.2 +/- 2.1)% vs (11.1 +/- 4.4)%, P < 0.01]. baPWV correlated with FMD (r = -0.68, P < 0.001). The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group. CONCLUSIONS: CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/17134584/Increased_brachial_ankle_pulse_wave_velocity_is_associated_with_impaired_endothelial_function_in_patients_with_coronary_artery_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=17134584 DB - PRIME DP - Unbound Medicine ER -