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Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum.
Neurosci Res 2007; 57(2):322-5NR

Abstract

Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl(-) concentration regulated by K(+)-Cl(-) co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.

Authors+Show Affiliations

Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Kita-15 Nishi-7, Sapporo, Japan. takachan@med.hokudai.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17134779

Citation

Takayama, Chitoshi, and Yoshiro Inoue. "Developmental Localization of Potassium Chloride Co-transporter 2 (KCC2) in the Purkinje Cells of Embryonic Mouse Cerebellum." Neuroscience Research, vol. 57, no. 2, 2007, pp. 322-5.
Takayama C, Inoue Y. Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. Neurosci Res. 2007;57(2):322-5.
Takayama, C., & Inoue, Y. (2007). Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. Neuroscience Research, 57(2), pp. 322-5.
Takayama C, Inoue Y. Developmental Localization of Potassium Chloride Co-transporter 2 (KCC2) in the Purkinje Cells of Embryonic Mouse Cerebellum. Neurosci Res. 2007;57(2):322-5. PubMed PMID: 17134779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. AU - Takayama,Chitoshi, AU - Inoue,Yoshiro, Y1 - 2006/11/28/ PY - 2006/09/08/received PY - 2006/10/20/revised PY - 2006/10/25/accepted PY - 2006/12/1/pubmed PY - 2007/4/18/medline PY - 2006/12/1/entrez SP - 322 EP - 5 JF - Neuroscience research JO - Neurosci. Res. VL - 57 IS - 2 N2 - Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl(-) concentration regulated by K(+)-Cl(-) co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer. SN - 0168-0102 UR - https://www.unboundmedicine.com/medline/citation/17134779/Developmental_localization_of_potassium_chloride_co_transporter_2__KCC2__in_the_Purkinje_cells_of_embryonic_mouse_cerebellum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(06)00290-2 DB - PRIME DP - Unbound Medicine ER -