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Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).
J Ethnopharmacol. 2007 Mar 21; 110(2):348-51.JE

Abstract

The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of 300mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (52.94%), whereas standard drug sucralfate showed 94.85%. Toona ciliata extract showed protection index 43.0% in water immersion stress induced ulcer, whereas standard drug omeprazole showed protection index 100%.

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Authors+Show Affiliations

Malairajan P
C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai 600096, Tamilnadu, India. pmalairajan@yahoo.co.in
Gopalakrishnan G
No affiliation info available
Narasimhan S
No affiliation info available
Veni KJ
No affiliation info available
Kavimani S
No affiliation info available

MeSH

AnimalsAnti-Ulcer AgentsAspirinDisease Models, AnimalEthanolFemaleLigationMaleMedicine, TraditionalMeliaceaeOmeprazolePhytotherapyPlant BarkPlant ExtractsPlants, MedicinalRatsRats, WistarStomach UlcerStress, PhysiologicalSucralfate

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17134860

Citation

Malairajan, P, et al. "Anti-ulcer Activity of Crude Alcoholic Extract of Toona Ciliata Roemer (heart Wood)." Journal of Ethnopharmacology, vol. 110, no. 2, 2007, pp. 348-51.
Malairajan P, Gopalakrishnan G, Narasimhan S, et al. Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). J Ethnopharmacol. 2007;110(2):348-51.
Malairajan, P., Gopalakrishnan, G., Narasimhan, S., Veni, K. J., & Kavimani, S. (2007). Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). Journal of Ethnopharmacology, 110(2), 348-51.
Malairajan P, et al. Anti-ulcer Activity of Crude Alcoholic Extract of Toona Ciliata Roemer (heart Wood). J Ethnopharmacol. 2007 Mar 21;110(2):348-51. PubMed PMID: 17134860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). AU - Malairajan,P, AU - Gopalakrishnan,Geetha, AU - Narasimhan,S, AU - Veni,K Jessi Kala, AU - Kavimani,S, Y1 - 2006/10/26/ PY - 2006/04/24/received PY - 2006/08/22/revised PY - 2006/10/12/accepted PY - 2006/12/1/pubmed PY - 2007/5/30/medline PY - 2006/12/1/entrez SP - 348 EP - 51 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 2 N2 - The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of 300mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (52.94%), whereas standard drug sucralfate showed 94.85%. Toona ciliata extract showed protection index 43.0% in water immersion stress induced ulcer, whereas standard drug omeprazole showed protection index 100%. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17134860/Anti_ulcer_activity_of_crude_alcoholic_extract_of_Toona_ciliata_Roemer__heart_wood__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00549-6 DB - PRIME DP - Unbound Medicine ER -