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Principles for vaccine protection in chickens and domestic waterfowl against avian influenza: emphasis on Asian H5N1 high pathogenicity avian influenza.
Ann N Y Acad Sci. 2006 Oct; 1081:174-81.AN

Abstract

The H5N1 highly pathogenic (HP) avian influenza (AI) epizootic began with reports of mortality from China in 1996 and, by June 2005, caused outbreaks of disease in nine additional Asian countries, affecting or resulting in culling of over 200 million birds. Vaccines can be used in programs to prevent, manage, or eradicate AI. However, vaccines should only be used as part of a comprehensive control strategy that also includes biosecurity, quarantine, surveillance and diagnostics, education, and elimination of infected poultry. Potent AI vaccines, when properly used, can prevent disease and death, increase resistance to infection, reduce field virus replication and shedding, and reduce virus transmission, but do not provide "sterilizing immunity" in the field; i.e., vaccination does not completely prevent AI virus replication. Inactivated AI vaccines and a recombinant fowlpox-H5-AI vaccine are licensed and used in various countries. Vaccines have been shown to protect chickens, geese, and ducks from H5 HPAI. The inactivated vaccines prevented disease and mortality in chickens and geese, and reduced the ability of the field virus to replicate in gastrointestinal and respiratory tracts. Although the Asian H5N1 HPAI virus did not cause disease or mortality in ducks, the use of inactivated vaccine did reduce field virus replication in the respiratory and intestinal tracts. The inactivated vaccine protected geese from morbidity and mortality, and reduced challenge virus replication. The recombinant fowlpox-H5-AI vaccine has provided similar protection, but the vaccine is used only in chickens and with the advantage of application at 1 day of age in the hatchery.

Authors+Show Affiliations

U.S. Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, Athens, GA 30605, USA. dswayne@seprl.usda.gov

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17135509

Citation

Swayne, David E.. "Principles for Vaccine Protection in Chickens and Domestic Waterfowl Against Avian Influenza: Emphasis On Asian H5N1 High Pathogenicity Avian Influenza." Annals of the New York Academy of Sciences, vol. 1081, 2006, pp. 174-81.
Swayne DE. Principles for vaccine protection in chickens and domestic waterfowl against avian influenza: emphasis on Asian H5N1 high pathogenicity avian influenza. Ann N Y Acad Sci. 2006;1081:174-81.
Swayne, D. E. (2006). Principles for vaccine protection in chickens and domestic waterfowl against avian influenza: emphasis on Asian H5N1 high pathogenicity avian influenza. Annals of the New York Academy of Sciences, 1081, 174-81.
Swayne DE. Principles for Vaccine Protection in Chickens and Domestic Waterfowl Against Avian Influenza: Emphasis On Asian H5N1 High Pathogenicity Avian Influenza. Ann N Y Acad Sci. 2006;1081:174-81. PubMed PMID: 17135509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Principles for vaccine protection in chickens and domestic waterfowl against avian influenza: emphasis on Asian H5N1 high pathogenicity avian influenza. A1 - Swayne,David E, PY - 2006/12/1/pubmed PY - 2007/4/21/medline PY - 2006/12/1/entrez SP - 174 EP - 81 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1081 N2 - The H5N1 highly pathogenic (HP) avian influenza (AI) epizootic began with reports of mortality from China in 1996 and, by June 2005, caused outbreaks of disease in nine additional Asian countries, affecting or resulting in culling of over 200 million birds. Vaccines can be used in programs to prevent, manage, or eradicate AI. However, vaccines should only be used as part of a comprehensive control strategy that also includes biosecurity, quarantine, surveillance and diagnostics, education, and elimination of infected poultry. Potent AI vaccines, when properly used, can prevent disease and death, increase resistance to infection, reduce field virus replication and shedding, and reduce virus transmission, but do not provide "sterilizing immunity" in the field; i.e., vaccination does not completely prevent AI virus replication. Inactivated AI vaccines and a recombinant fowlpox-H5-AI vaccine are licensed and used in various countries. Vaccines have been shown to protect chickens, geese, and ducks from H5 HPAI. The inactivated vaccines prevented disease and mortality in chickens and geese, and reduced the ability of the field virus to replicate in gastrointestinal and respiratory tracts. Although the Asian H5N1 HPAI virus did not cause disease or mortality in ducks, the use of inactivated vaccine did reduce field virus replication in the respiratory and intestinal tracts. The inactivated vaccine protected geese from morbidity and mortality, and reduced challenge virus replication. The recombinant fowlpox-H5-AI vaccine has provided similar protection, but the vaccine is used only in chickens and with the advantage of application at 1 day of age in the hatchery. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17135509/Principles_for_vaccine_protection_in_chickens_and_domestic_waterfowl_against_avian_influenza:_emphasis_on_Asian_H5N1_high_pathogenicity_avian_influenza_ L2 - https://doi.org/10.1196/annals.1373.021 DB - PRIME DP - Unbound Medicine ER -