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Vaccines developed for H5 highly pathogenic avian influenza in China.
Ann N Y Acad Sci. 2006 Oct; 1081:182-92.AN

Abstract

Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, and was used for the buffer zone vaccination in the H5N1 outbreaks in 2004 in China. We also generated a low pathogenic H5N1 reassortant virus A/Harbin/Re-1/2003 (Re-1) that derives its HA and NA genes from GSGD/96 virus and six internal genes from the high-growth A/Puerto Rico/8/34 (PR8) virus by using plasmid-based reverse genetics. The inactivated vaccine derived from Re-1 strain could induce more than 10 months protective immune response in chickens after one dose inoculation, and most importantly, this vaccine is immunogenic for geese and ducks. An H5N1 fowlpox vectored live vaccine was also generated by inserting the HA and NA genes of GSGD/96 virus in the genome of a fowlpox vaccine strain. Laboratory tests indicated that after one dose of immunization of this vaccine, chickens could develop an over than 40 weeks protective immune response against H5N1 virus challenge.

Authors+Show Affiliations

Animal Influenza Laboratory of the Ministry of Agriculture, Harbin 150001, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17135510

Citation

Qiao, Chuanling, et al. "Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China." Annals of the New York Academy of Sciences, vol. 1081, 2006, pp. 182-92.
Qiao C, Tian G, Jiang Y, et al. Vaccines developed for H5 highly pathogenic avian influenza in China. Ann N Y Acad Sci. 2006;1081:182-92.
Qiao, C., Tian, G., Jiang, Y., Li, Y., Shi, J., Yu, K., & Chen, H. (2006). Vaccines developed for H5 highly pathogenic avian influenza in China. Annals of the New York Academy of Sciences, 1081, 182-92.
Qiao C, et al. Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China. Ann N Y Acad Sci. 2006;1081:182-92. PubMed PMID: 17135510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccines developed for H5 highly pathogenic avian influenza in China. AU - Qiao,Chuanling, AU - Tian,Guobin, AU - Jiang,Yongping, AU - Li,Yanbing, AU - Shi,Jianzhong, AU - Yu,Kangzhen, AU - Chen,Hualan, PY - 2006/12/1/pubmed PY - 2007/4/21/medline PY - 2006/12/1/entrez SP - 182 EP - 92 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1081 N2 - Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, and was used for the buffer zone vaccination in the H5N1 outbreaks in 2004 in China. We also generated a low pathogenic H5N1 reassortant virus A/Harbin/Re-1/2003 (Re-1) that derives its HA and NA genes from GSGD/96 virus and six internal genes from the high-growth A/Puerto Rico/8/34 (PR8) virus by using plasmid-based reverse genetics. The inactivated vaccine derived from Re-1 strain could induce more than 10 months protective immune response in chickens after one dose inoculation, and most importantly, this vaccine is immunogenic for geese and ducks. An H5N1 fowlpox vectored live vaccine was also generated by inserting the HA and NA genes of GSGD/96 virus in the genome of a fowlpox vaccine strain. Laboratory tests indicated that after one dose of immunization of this vaccine, chickens could develop an over than 40 weeks protective immune response against H5N1 virus challenge. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17135510/Vaccines_developed_for_H5_highly_pathogenic_avian_influenza_in_China_ L2 - https://doi.org/10.1196/annals.1373.022 DB - PRIME DP - Unbound Medicine ER -