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Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women.
Obesity (Silver Spring). 2006 Nov; 14(11):1954-60.O

Abstract

OBJECTIVE

To examine whether obesity and insulin resistance have an independent effect on the gonadotropin, estradiol, and inhibin B serum levels and follicle count in the early follicular phase of fertile women with a wide range of BMI and without signs of hyperandrogenism.

RESEARCH METHODS AND PROCEDURES

Twenty-two overweight and obese (BMI > or =25.0 kg/m(2)) women and 10 normal-weight (BMI <25.0 kg/m(2)) women, all having apparently normal fertility, were studied. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, inhibin B, and insulin, level of insulin resistance (estimated by homeostasis model assessment for insulin resistance), and follicle count were measured during the early follicular phase (Days 2 to 5 of the menstrual cycle).

RESULTS

Overweight women showed lower FSH (p < 0.001), LH (p < 0.001), and inhibin B (p < 0.05) levels compared with normal-weight women, whereas estradiol concentrations and follicle count were not significantly different between the two groups. When normal-weight and overweight women were examined as a group and multiple regression analyses were performed, estradiol showed a negative association with BMI (or waist circumference) (p < 0.05) and a positive correlation with LH (p < 0.05) and FSH (p < 0.05); inhibin B maintained a positive association only with estradiol (p < 0.05); and FSH and LH showed a negative correlation with BMI (or waist circumference) (p < 0.001 and p < 0.01, respectively).

DISCUSSION

Overweight and obese fertile women have lower FSH, LH, inhibin B, and estradiol levels in the early follicular phase, with a possible direct inhibitory effect of body mass on gonadotropin and estradiol production, independently of age, insulin (concentrations and sensitivity), and other hormones. By contrast, the number of ovary follicles does not seem to be influenced by insulin and body mass in these patients.

Authors+Show Affiliations

Section of Internal Medicine, Endocrinology, and Metabolic Disease, Department of Emergency and Organ Transplantation, Bari, Italy. g.depergola@endo.uniba.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17135611

Citation

De Pergola, Giovanni, et al. "Inhibitory Effect of Obesity On Gonadotropin, Estradiol, and Inhibin B Levels in Fertile Women." Obesity (Silver Spring, Md.), vol. 14, no. 11, 2006, pp. 1954-60.
De Pergola G, Maldera S, Tartagni M, et al. Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. Obesity (Silver Spring). 2006;14(11):1954-60.
De Pergola, G., Maldera, S., Tartagni, M., Pannacciulli, N., Loverro, G., & Giorgino, R. (2006). Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. Obesity (Silver Spring, Md.), 14(11), 1954-60.
De Pergola G, et al. Inhibitory Effect of Obesity On Gonadotropin, Estradiol, and Inhibin B Levels in Fertile Women. Obesity (Silver Spring). 2006;14(11):1954-60. PubMed PMID: 17135611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. AU - De Pergola,Giovanni, AU - Maldera,Simona, AU - Tartagni,Massimo, AU - Pannacciulli,Nicola, AU - Loverro,Giuseppe, AU - Giorgino,Riccardo, PY - 2006/12/1/pubmed PY - 2007/2/16/medline PY - 2006/12/1/entrez SP - 1954 EP - 60 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 IS - 11 N2 - OBJECTIVE: To examine whether obesity and insulin resistance have an independent effect on the gonadotropin, estradiol, and inhibin B serum levels and follicle count in the early follicular phase of fertile women with a wide range of BMI and without signs of hyperandrogenism. RESEARCH METHODS AND PROCEDURES: Twenty-two overweight and obese (BMI > or =25.0 kg/m(2)) women and 10 normal-weight (BMI <25.0 kg/m(2)) women, all having apparently normal fertility, were studied. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, inhibin B, and insulin, level of insulin resistance (estimated by homeostasis model assessment for insulin resistance), and follicle count were measured during the early follicular phase (Days 2 to 5 of the menstrual cycle). RESULTS: Overweight women showed lower FSH (p < 0.001), LH (p < 0.001), and inhibin B (p < 0.05) levels compared with normal-weight women, whereas estradiol concentrations and follicle count were not significantly different between the two groups. When normal-weight and overweight women were examined as a group and multiple regression analyses were performed, estradiol showed a negative association with BMI (or waist circumference) (p < 0.05) and a positive correlation with LH (p < 0.05) and FSH (p < 0.05); inhibin B maintained a positive association only with estradiol (p < 0.05); and FSH and LH showed a negative correlation with BMI (or waist circumference) (p < 0.001 and p < 0.01, respectively). DISCUSSION: Overweight and obese fertile women have lower FSH, LH, inhibin B, and estradiol levels in the early follicular phase, with a possible direct inhibitory effect of body mass on gonadotropin and estradiol production, independently of age, insulin (concentrations and sensitivity), and other hormones. By contrast, the number of ovary follicles does not seem to be influenced by insulin and body mass in these patients. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17135611/Inhibitory_effect_of_obesity_on_gonadotropin_estradiol_and_inhibin_B_levels_in_fertile_women_ L2 - https://doi.org/10.1038/oby.2006.228 DB - PRIME DP - Unbound Medicine ER -