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Effect on hematologic risk factors for coronary heart disease of a cholesterol reducing diet.
Eur J Clin Nutr 2007; 61(4):483-92EJ

Abstract

BACKGROUND

A dietary portfolio of cholesterol-lowering ingredients has proved effective in reducing serum cholesterol. However, it is not known whether this dietary combination will also affect hematologic risk factors for coronary heart disease (CHD). Reductions in hematocrit and polymorphonuclear leukocytes have been reported to improve cardiovascular risk. We, therefore, report changes in hematological indices, which have been linked to cardiovascular health, in a 1-year assessment of subjects taking an effective dietary combination (portfolio) of cholesterol-lowering foods.

METHODS

For 12 months, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (23 g/1000 kcal). Fifty-five subjects completed the study.

RESULTS

Over the 1 year, data on completers indicated small but significant reductions in hemoglobin (-1.5+/-0.6 g/l, P=0.013), hematocrit (-0.007+/-0.002 l/l, P<0.001), red cell number (-0.07+/-0.02 10(9)/l, P<0.001) and neutrophils (-0.34+/-0.13 10(9)/l, P=0.014). Mean platelet volume was also increased (0.16+/-0.07 fl, P=0.033). The increase in red cell osmotic fragility (0.05+/-0.03 g/l, P=0.107) did not reach significance.

CONCLUSIONS

These small changes in hematological indices after a cholesterol-lowering diet are in the direction, which would be predicted to reduce CHD risk. Further research is needed to clarify whether the changes observed will contribute directly or indirectly to cardiovascular benefits beyond those expected from reductions previously seen in serum lipids and blood pressure.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Clinical Nutrition & Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17136042

Citation

Jenkins, D J A., et al. "Effect On Hematologic Risk Factors for Coronary Heart Disease of a Cholesterol Reducing Diet." European Journal of Clinical Nutrition, vol. 61, no. 4, 2007, pp. 483-92.
Jenkins DJ, Kendall CW, Nguyen TH, et al. Effect on hematologic risk factors for coronary heart disease of a cholesterol reducing diet. Eur J Clin Nutr. 2007;61(4):483-92.
Jenkins, D. J., Kendall, C. W., Nguyen, T. H., Teitel, J., Marchie, A., Chiu, M., ... Singer, W. (2007). Effect on hematologic risk factors for coronary heart disease of a cholesterol reducing diet. European Journal of Clinical Nutrition, 61(4), pp. 483-92.
Jenkins DJ, et al. Effect On Hematologic Risk Factors for Coronary Heart Disease of a Cholesterol Reducing Diet. Eur J Clin Nutr. 2007;61(4):483-92. PubMed PMID: 17136042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect on hematologic risk factors for coronary heart disease of a cholesterol reducing diet. AU - Jenkins,D J A, AU - Kendall,C W C, AU - Nguyen,T H, AU - Teitel,J, AU - Marchie,A, AU - Chiu,M, AU - Taha,A Y, AU - Faulkner,D A, AU - Kemp,T, AU - Wong,J M W, AU - de Souza,R, AU - Emam,A, AU - Trautwein,E A, AU - Lapsley,K G, AU - Holmes,C, AU - Josse,R G, AU - Leiter,L A, AU - Singer,W, Y1 - 2006/11/29/ PY - 2006/12/1/pubmed PY - 2007/5/30/medline PY - 2006/12/1/entrez SP - 483 EP - 92 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 4 N2 - BACKGROUND: A dietary portfolio of cholesterol-lowering ingredients has proved effective in reducing serum cholesterol. However, it is not known whether this dietary combination will also affect hematologic risk factors for coronary heart disease (CHD). Reductions in hematocrit and polymorphonuclear leukocytes have been reported to improve cardiovascular risk. We, therefore, report changes in hematological indices, which have been linked to cardiovascular health, in a 1-year assessment of subjects taking an effective dietary combination (portfolio) of cholesterol-lowering foods. METHODS: For 12 months, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (23 g/1000 kcal). Fifty-five subjects completed the study. RESULTS: Over the 1 year, data on completers indicated small but significant reductions in hemoglobin (-1.5+/-0.6 g/l, P=0.013), hematocrit (-0.007+/-0.002 l/l, P<0.001), red cell number (-0.07+/-0.02 10(9)/l, P<0.001) and neutrophils (-0.34+/-0.13 10(9)/l, P=0.014). Mean platelet volume was also increased (0.16+/-0.07 fl, P=0.033). The increase in red cell osmotic fragility (0.05+/-0.03 g/l, P=0.107) did not reach significance. CONCLUSIONS: These small changes in hematological indices after a cholesterol-lowering diet are in the direction, which would be predicted to reduce CHD risk. Further research is needed to clarify whether the changes observed will contribute directly or indirectly to cardiovascular benefits beyond those expected from reductions previously seen in serum lipids and blood pressure. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17136042/Effect_on_hematologic_risk_factors_for_coronary_heart_disease_of_a_cholesterol_reducing_diet_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602551 DB - PRIME DP - Unbound Medicine ER -