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The rate of conversion of mild cognitive impairment to dementia: predictive role of depression.
Int J Geriatr Psychiatry 2007; 22(6):563-7IJ

Abstract

BACKGROUND

Mild cognitive impairment (MCI) is a condition referring to the persons with cognitive deficits measurable in some form or another, but not meeting criteria for dementia, and who have an increased risk of becoming demented.

OBJECTIVE

To establish the rate of progression to dementia in MCI, to investigate the risk of conversion for amnestic vs multiple-domains subtypes, and to identify the predictors of progression.

METHODS

MCI (n = 105) individuals enrolled in a longitudinal study received annual clinical and psychometric examinations for up to a mean of 3 years. The diagnosis of MCI according to Mayo Clinic Petersen's Criteria was conducted by a panel of specialists.

RESULTS

After 3 years of follow-up, 23 of 105 subjects with MCI were diagnosed with dementia. 40 showed cognitive decline not dementia, 34 were stable and showed no cognitive decline or improvement, while eight showed cognitive improvement.

CONCLUSIONS

We conclude that conversion rate from MCI to DSM-IIIR dementia was 21.9% over a period of 3 years. The occurrence of depressive symptoms may constitute a predictor for those who are more likely to progress to dementia. The risk of conversion to dementia was higher among the subjects with an evidence of impairment extending beyond memory than with those who suffered only from memory deficits, and the subjects who converted to dementia in this subtype had significantly higher baseline plasma total homocysteine levels than non-converters.

Authors+Show Affiliations

Department of Neurodegenerative Disorders, Medical Research Centre Polish Academy of Sciences, Warsaw, Poland. gabryelewicz@cmdik.pan.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17136705

Citation

Gabryelewicz, T, et al. "The Rate of Conversion of Mild Cognitive Impairment to Dementia: Predictive Role of Depression." International Journal of Geriatric Psychiatry, vol. 22, no. 6, 2007, pp. 563-7.
Gabryelewicz T, Styczynska M, Luczywek E, et al. The rate of conversion of mild cognitive impairment to dementia: predictive role of depression. Int J Geriatr Psychiatry. 2007;22(6):563-7.
Gabryelewicz, T., Styczynska, M., Luczywek, E., Barczak, A., Pfeffer, A., Androsiuk, W., ... Barcikowska, M. (2007). The rate of conversion of mild cognitive impairment to dementia: predictive role of depression. International Journal of Geriatric Psychiatry, 22(6), pp. 563-7.
Gabryelewicz T, et al. The Rate of Conversion of Mild Cognitive Impairment to Dementia: Predictive Role of Depression. Int J Geriatr Psychiatry. 2007;22(6):563-7. PubMed PMID: 17136705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The rate of conversion of mild cognitive impairment to dementia: predictive role of depression. AU - Gabryelewicz,T, AU - Styczynska,M, AU - Luczywek,E, AU - Barczak,A, AU - Pfeffer,A, AU - Androsiuk,W, AU - Chodakowska-Zebrowska,M, AU - Wasiak,B, AU - Peplonska,B, AU - Barcikowska,M, PY - 2006/12/1/pubmed PY - 2007/12/13/medline PY - 2006/12/1/entrez SP - 563 EP - 7 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 22 IS - 6 N2 - BACKGROUND: Mild cognitive impairment (MCI) is a condition referring to the persons with cognitive deficits measurable in some form or another, but not meeting criteria for dementia, and who have an increased risk of becoming demented. OBJECTIVE: To establish the rate of progression to dementia in MCI, to investigate the risk of conversion for amnestic vs multiple-domains subtypes, and to identify the predictors of progression. METHODS: MCI (n = 105) individuals enrolled in a longitudinal study received annual clinical and psychometric examinations for up to a mean of 3 years. The diagnosis of MCI according to Mayo Clinic Petersen's Criteria was conducted by a panel of specialists. RESULTS: After 3 years of follow-up, 23 of 105 subjects with MCI were diagnosed with dementia. 40 showed cognitive decline not dementia, 34 were stable and showed no cognitive decline or improvement, while eight showed cognitive improvement. CONCLUSIONS: We conclude that conversion rate from MCI to DSM-IIIR dementia was 21.9% over a period of 3 years. The occurrence of depressive symptoms may constitute a predictor for those who are more likely to progress to dementia. The risk of conversion to dementia was higher among the subjects with an evidence of impairment extending beyond memory than with those who suffered only from memory deficits, and the subjects who converted to dementia in this subtype had significantly higher baseline plasma total homocysteine levels than non-converters. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/17136705/The_rate_of_conversion_of_mild_cognitive_impairment_to_dementia:_predictive_role_of_depression_ L2 - https://doi.org/10.1002/gps.1716 DB - PRIME DP - Unbound Medicine ER -