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Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite.
Asian Pac J Allergy Immunol. 2006 Jun-Sep; 24(2-3):117-21.AP

Abstract

The aim of this study was to evaluate rhinomanometric responses to nasal allergen provocation in children with allergic rhinitis sensitized to house dust mite. We studied 51 children, aged 6-16 years (mean: 11.5 +/- 2.6 years), with clinical symptoms of perennial allergic rhinitis without asthma and 20 non-atopic healthy controls in the same age range (mean: 11.8 +/- 3.8 years). All of the patients had positive skin prick test (SPT) results and serum specific IgE above 0.70 kU/l to Dermatophagoides pteronyssinus (Dp). Nasal provocation testing (NPT) was performed with increasing concentrations of Dp extracts and the nasal response was evaluated by active anterior rhinomanometry. A 100% increase of resistance in one or both nasal cavities was considered positive. There was a statistically significant difference of baseline nasal resistance (total, right and left sides) between the control and the patient groups (p < 0.001). A positive response to house dust mite allergens was recorded in 47/51 (92.2%) patients by rhinomanometry. The NPT presented no significant correlation with age, weight, height, SPT diameter, serum total and specific IgE levels to Dp and baseline nasal airway resistance values. This study suggests that a nasal provocation test with allergen is unnecessary in children with positive skin prick test and serum IgE specific to house dust mite. The rhinomanometric response to the allergen provocation does not correlate with the diameter of the skin prick test and the level of serum specific IgE.

Authors+Show Affiliations

Division of Allergy, Department of Pediatrics, Istanbul Zeynep Kamil Hospital, Istanbul, Turkey. kirerleri@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17136876

Citation

Kirerleri, E, et al. "Evaluation of the Nasal Provocation Test for Its Necessity in the Diagnosis of Nasal Allergy to House Dust Mite." Asian Pacific Journal of Allergy and Immunology, vol. 24, no. 2-3, 2006, pp. 117-21.
Kirerleri E, Guler N, Tamay Z, et al. Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite. Asian Pac J Allergy Immunol. 2006;24(2-3):117-21.
Kirerleri, E., Guler, N., Tamay, Z., & Ones, U. (2006). Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite. Asian Pacific Journal of Allergy and Immunology, 24(2-3), 117-21.
Kirerleri E, et al. Evaluation of the Nasal Provocation Test for Its Necessity in the Diagnosis of Nasal Allergy to House Dust Mite. Asian Pac J Allergy Immunol. 2006;24(2-3):117-21. PubMed PMID: 17136876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite. AU - Kirerleri,E, AU - Guler,N, AU - Tamay,Z, AU - Ones,U, PY - 2006/12/2/pubmed PY - 2007/1/19/medline PY - 2006/12/2/entrez SP - 117 EP - 21 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac. J. Allergy Immunol. VL - 24 IS - 2-3 N2 - The aim of this study was to evaluate rhinomanometric responses to nasal allergen provocation in children with allergic rhinitis sensitized to house dust mite. We studied 51 children, aged 6-16 years (mean: 11.5 +/- 2.6 years), with clinical symptoms of perennial allergic rhinitis without asthma and 20 non-atopic healthy controls in the same age range (mean: 11.8 +/- 3.8 years). All of the patients had positive skin prick test (SPT) results and serum specific IgE above 0.70 kU/l to Dermatophagoides pteronyssinus (Dp). Nasal provocation testing (NPT) was performed with increasing concentrations of Dp extracts and the nasal response was evaluated by active anterior rhinomanometry. A 100% increase of resistance in one or both nasal cavities was considered positive. There was a statistically significant difference of baseline nasal resistance (total, right and left sides) between the control and the patient groups (p < 0.001). A positive response to house dust mite allergens was recorded in 47/51 (92.2%) patients by rhinomanometry. The NPT presented no significant correlation with age, weight, height, SPT diameter, serum total and specific IgE levels to Dp and baseline nasal airway resistance values. This study suggests that a nasal provocation test with allergen is unnecessary in children with positive skin prick test and serum IgE specific to house dust mite. The rhinomanometric response to the allergen provocation does not correlate with the diameter of the skin prick test and the level of serum specific IgE. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/17136876/Evaluation_of_the_nasal_provocation_test_for_its_necessity_in_the_diagnosis_of_nasal_allergy_to_house_dust_mite_ L2 - http://apjai-journal.org/wp-content/uploads/2018/01/5EvaluationoftheNasalVol24No2-3June-Sep2006P117.pdf DB - PRIME DP - Unbound Medicine ER -