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[Deep-vein thrombosis and pulmonary embolism due to air travel].
Ned Tijdschr Geneeskd. 2006 Nov 11; 150(45):2474-8.NT

Abstract

In recent years, the association between air travel and the incidence of deep-vein thrombosis or pulmonary embolism has become clearer. Epidemiologic studies reveal an increased relative risk of thromboembolism after flights of more than 8 hours and especially in subjects at higher risk for this disease, due, for example, to congenital thrombophilia or the use of oral contraceptives. However, the absolute risk of deep-vein thrombosis or pulmonary embolism after prolonged air travel is very small. Studies have shown that a combination of factors present during prolonged air travel may account for increased activation of coagulation. There is no definitive proof that elastic stockings are effective in reducing the incidence of clinically relevant thromboembolism during air travel. Acetylsalicylic acid is not effective in the prevention of thrombosis during air travel and may be dangerous. Prophylactic subcutaneous low molecular weight heparin may be effective to prevent air travel-associated thrombosis. However, pending more solid evidence, this strategy should only be used cautiously, e.g. only in patients with a high risk of thrombosis who are planning a long flight.

Authors+Show Affiliations

Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde, onderafd. Vasculaire Geneeskunde, F-4, Meiberg-dreef 9, 1105 AZ Amsterdam. m.m.levi@amc.uva.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Comment
English Abstract
Journal Article
Review

Language

dut

PubMed ID

17137092

Citation

Levi, M, et al. "[Deep-vein Thrombosis and Pulmonary Embolism Due to Air Travel]." Nederlands Tijdschrift Voor Geneeskunde, vol. 150, no. 45, 2006, pp. 2474-8.
Levi M, Rosendaal FR, Büller HR. [Deep-vein thrombosis and pulmonary embolism due to air travel]. Ned Tijdschr Geneeskd. 2006;150(45):2474-8.
Levi, M., Rosendaal, F. R., & Büller, H. R. (2006). [Deep-vein thrombosis and pulmonary embolism due to air travel]. Nederlands Tijdschrift Voor Geneeskunde, 150(45), 2474-8.
Levi M, Rosendaal FR, Büller HR. [Deep-vein Thrombosis and Pulmonary Embolism Due to Air Travel]. Ned Tijdschr Geneeskd. 2006 Nov 11;150(45):2474-8. PubMed PMID: 17137092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Deep-vein thrombosis and pulmonary embolism due to air travel]. AU - Levi,M, AU - Rosendaal,F R, AU - Büller,H R, PY - 2006/12/2/pubmed PY - 2007/2/1/medline PY - 2006/12/2/entrez SP - 2474 EP - 8 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 150 IS - 45 N2 - In recent years, the association between air travel and the incidence of deep-vein thrombosis or pulmonary embolism has become clearer. Epidemiologic studies reveal an increased relative risk of thromboembolism after flights of more than 8 hours and especially in subjects at higher risk for this disease, due, for example, to congenital thrombophilia or the use of oral contraceptives. However, the absolute risk of deep-vein thrombosis or pulmonary embolism after prolonged air travel is very small. Studies have shown that a combination of factors present during prolonged air travel may account for increased activation of coagulation. There is no definitive proof that elastic stockings are effective in reducing the incidence of clinically relevant thromboembolism during air travel. Acetylsalicylic acid is not effective in the prevention of thrombosis during air travel and may be dangerous. Prophylactic subcutaneous low molecular weight heparin may be effective to prevent air travel-associated thrombosis. However, pending more solid evidence, this strategy should only be used cautiously, e.g. only in patients with a high risk of thrombosis who are planning a long flight. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/17137092/[Deep_vein_thrombosis_and_pulmonary_embolism_due_to_air_travel]_ L2 - http://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -